Document Detail

Cerebral circulatory and metabolic changes following EC/IC bypass surgery in cerebral occlusive diseases.
MedLine Citation:
PMID:  8099216     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the effect of extracranial-intracranial (EC/IC) bypass surgery for the patients with ischaemic cerebrovascular disease, fourteen patients were studied for cerebral blood flow (CBF), oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) before and after EC/IC bypass using positron emission tomography (PET) and 15O steady state technique. Six patients with carotid lesion received superficial temporal artery (STA)-middle cerebral artery anastomosis, and eight patients with vertebro-basilar lesion underwent STA-superior cerebellar artery anastomosis. In both groups of patients with carotid and vertebro-basilar lesion, significant increase of CBF and decrease of OEF were observed following surgical revascularization. Especially in patients with vertebro-basilar lesion, remarkable improvements were observed not only in the cerebellum but also in the cerebral cortex. In addition, the cases with preoperative higher OEF showed marked increase of CBF and decrease of OEF. It was suggested that EC/IC bypass can be effective when pre-operative uncoupling between cerebral circulation and metabolism are marked and PET study provides useful information for selecting the appropriate candidates for EC/IC bypass surgery.
K Muraishi; M Kameyama; K Sato; R Sirane; A Ogawa; T Yoshimoto; J Hatazawa; M Itoh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  15     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-29     Completed Date:  1993-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  97-103     Citation Subset:  IM    
Division of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Brain / metabolism
Brain Ischemia / metabolism,  physiopathology*,  radionuclide imaging,  surgery*
Carotid Artery Diseases / radionuclide imaging,  surgery
Cerebral Revascularization*
Cerebrovascular Circulation / physiology*
Follow-Up Studies
Preoperative Care
Tomography, Emission-Computed
Vertebrobasilar Insufficiency / radionuclide imaging,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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