| Cerebral cavernous malformations with dynamic and progressive course: correlation study with vascular endothelial growth factor. | |
| | |
MedLine Citation:
|
PMID: 14623736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cerebral cavernous malformations (CCMs) are reported to exhibit a wide range of dynamic patterns including growth, regression, and de novo formation, which generally show slow and steady courses. Although the pathogenesis of CCMs is not well known, vascular endothelial growth factor (VEGF) has been suggested as a possible mediating factor. OBJECTIVES: To report CCMs showing rapid progression over a short period and to investigate these biological characteristics. DESIGN: Experimental study. SETTING: Tertiary referral center, neurology department. Patient A 40-year-old man was admitted because of a left-sided numbness, vertigo, and ataxia, which were attributed to a pontine hemorrhage. He had experienced a left-sided weakness 6 months before admission, and thereafter had complained of intermittent headache. Serial brain magnetic resonance images showed multiple intracerebral microhemorrhages throughout the cerebral hemispheres. A biopsy of the lesion confirmed the diagnosis of CCM. MAIN OUTCOME MEASURES: We investigated the expression of VEGF by immunohistochemistry of the biopsy specimen. Dynamic patterns of CCMs, obtained with spin-echo magnetic resonance images with gradient-echo sequences, were compared with serial serum VEGF concentrations, determined by enzyme-linked immunosorbent assay. RESULTS: Immunohistochemistry of the specimen displayed increased VEGF expression. Serial magnetic resonance images during 7 months showed dynamic signal changes of the preexisting lesions and 15 de novo formations in many cortices. The VEGF level in serum increased during this dynamic period and became normal during the steady and resolving stages. CONCLUSIONS: Cerebral cavernous malformations can be progressively deteriorating. The endothelial proliferation induced by VEGF is likely to be an important aspect of the pathogenetic mechanisms of CCMs. |
| | |
Authors:
|
Keun-Hwa Jung; Kon Chu; Sang-Wuk Jeong; Hee-Kwon Park; Hee-Joon Bae; Byung-Woo Yoon |
Related Documents
:
|
20833496 - Evaluation of time-intensity curves in ductal carcinoma in situ (dcis) and mastopathy o... 19668716 - Correlation of histological findings from a large ciliochoroidal melanoma with ct perfu... 15665696 - Evaluation of extraocular muscles using dynamic contrast enhanced mri in patients with ... 1623276 - Dynamic study of the upper airway with ultrafast spoiled grass mr imaging. 2719356 - Magnetic resonance imaging of the paranasal sinuses: frequency and type of abnormalities. 15451356 - Multidetector-row ct duodenography in familial adenomatous polyposis: a pilot study. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Archives of neurology Volume: 60 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2003-11-18 Completed Date: 2003-12-10 Revised Date: 2009-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 1613-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology and Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cerebral Hemorrhage / etiology, pathology Disease Progression Enzyme-Linked Immunosorbent Assay Frontal Lobe / metabolism, pathology* Hemangioma, Cavernous, Central Nervous System / complications, metabolism*, pathology* Humans Immunohistochemistry Magnetic Resonance Imaging Male Vascular Endothelial Growth Factor A / blood, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multifocal varicella-zoster virus vasculopathy without rash.
Next Document: Spasmus nutans and congenital ocular motor apraxia with cerebellar vermian hypoplasia.