Document Detail


Cerebral cavernomas and human leukocyte antigens: preliminary clinical results.
MedLine Citation:
PMID:  17662350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although cavernomas are the most common brain vascular malformations, the etiology and risk factor(s) are still not entirely known. Recent publications focusing on the molecular basis suggest that genetic factors may play a role in the development of the brain vascular malformations. We aimed to show HLA typing in brain cavernoma in a group of Turkish patients. METHODS: This study compared HLA types of 30 patients who had brain cavernoma with 30 healthy controls. RESULTS: The analysis of HLA distribution in the patients, compared with healthy control data, revealed some statistically significant differences, even after the more rigid Bonferoni correction (P(c)). In the patients group, the frequency of following HLA antigens was significantly increased compared with the control group: HLA-A1 (P(c): .005), HLA-A24 (P(c): .02), HLA-A32 (P(c): .01), HLA-B51 (P(c): .00001), HLA-DR1 (P(c): .02), and HLA-DR4 (P(c): .004). CONCLUSION: These preliminary data suggest that brain cavernoma susceptibility may be associated with HLA antigens. Further studies should be designed to include a larger population of patients with brain cavernoma in order to expose whether there is association between HLA typing and occurrence of cavernoma more accurately.
Authors:
Galip Zihni Sanus; Hakan Hanimoglu; Taner Tanriverdi; Erkan Yilmaz; Halil Ak; Mustafa Onur Ulu; Ali Metin Kafadar; Bulent Canbaz; Mehmet Yasar Kaynar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  68     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-6; discussion 167     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34301, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Neoplasms / genetics*,  immunology
Case-Control Studies
Female
Gene Frequency*
Genetic Predisposition to Disease
HLA-A Antigens / genetics*
HLA-B Antigens / genetics*
HLA-DR Antigens / genetics*
Hemangioma, Cavernous, Central Nervous System / genetics*,  immunology
Histocompatibility Testing
Humans
Male
Middle Aged
Turkey
Chemical
Reg. No./Substance:
0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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