Document Detail

Cerebral calcification and learning disabilities following cranial irradiation for medulloblastoma.
MedLine Citation:
PMID:  2280428     Owner:  NLM     Status:  MEDLINE    
Six children who received craniospinal irradiation for medulloblastoma when they were under 10 years of age developed learning disabilities. Four exhibited associated temporal lobe calcification on computerized tomography of the brain. The pathogenetic mechanisms of postirradiation cerebral calcification and learning disabilities in these children are discussed. We present the hypothesis that irradiation-induced vasculopathy results in hypoxia, most pronounced in the hippocampus. Hippocampal damage can manifest radiologically as calcifications and clinically as memory and learning disabilities.
O Abayomi; M S Chun; K Kelly
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  82     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-03-08     Completed Date:  1991-03-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  833-6     Citation Subset:  IM    
Department of Radiation Oncology, Howard University, Washington, DC 20060.
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MeSH Terms
Brain Diseases / complications,  etiology*,  radiography
Brain Neoplasms / mortality,  radiotherapy*
Calcinosis / complications,  etiology*,  radiography
Child, Preschool
Follow-Up Studies
Learning Disorders / diagnosis,  etiology*
Medulloblastoma / mortality,  radiotherapy*
Neuropsychological Tests
Radiotherapy / adverse effects*
Retrospective Studies
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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