Document Detail


Cerebral blood volume MRI with intravascular superparamagnetic iron oxide nanoparticles.
MedLine Citation:
PMID:  23208650     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cerebral blood volume (CBV) is a crucial physiological indicator of tissue viability and vascular reactivity. Thus, noninvasive CBV mapping has been of great interest. For this, ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, including monocrystalline iron oxide nanoparticles, can be used as long-half-life, intravascular susceptibility agents of CBV MRI measurements. Moreover, CBV-weighted functional MRI (fMRI) with USPIO nanoparticles provides enhanced sensitivity, reduced large vessel contribution and improved spatial specificity relative to conventional blood oxygenation level-dependent fMRI, and measures a single physiological parameter that is easily interpretable. We review the physiochemical and magnetic properties, and pharmacokinetics, of USPIO nanoparticles in brief. We then extensively discuss quantifications of baseline CBV, vessel size index and functional CBV change. We also provide reviews of dose-dependent sensitivity, vascular filter function, specificity, characteristics and impulse response function of CBV fMRI. Examples of CBV fMRI specificity at the laminar and columnar resolution are provided. Finally, we briefly review the application of CBV measurements to functional and pharmacological studies in animals. Overall, the use of USPIO nanoparticles can determine baseline CBV and its changes induced by functional activity and pharmacological interventions.
Authors:
Seong-Gi Kim; Noam Harel; Tao Jin; Tae Kim; Phil Lee; Fuqiang Zhao
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-12-04
Journal Detail:
Title:  NMR in biomedicine     Volume:  26     ISSN:  1099-1492     ISO Abbreviation:  NMR Biomed     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2014-04-11     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  England    
Other Details:
Languages:  eng     Pagination:  949-62     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / anatomy & histology
Blood Volume
Brain / blood supply,  metabolism
Brain Ischemia / pathology
Cerebral Arteries / anatomy & histology
Cerebrovascular Circulation*
Contrast Media / administration & dosage,  chemistry,  diagnostic use*,  pharmacokinetics
Dextrans / administration & dosage,  chemistry,  diagnostic use*,  pharmacokinetics
Half-Life
Humans
Magnetic Resonance Angiography / methods
Magnetic Resonance Imaging / methods*
Magnetite Nanoparticles / administration & dosage,  chemistry,  diagnostic use*
Microcirculation
Motor Activity
Neurosciences / methods
Oxygen / blood*
Sensitivity and Specificity
Venules / anatomy & histology
Grant Support
ID/Acronym/Agency:
EB003324/EB/NIBIB NIH HHS; EB003375/EB/NIBIB NIH HHS; NS44589/NS/NINDS NIH HHS; R01 EB003324/EB/NIBIB NIH HHS; R01 EB003375/EB/NIBIB NIH HHS; R01 NS044589/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Magnetite Nanoparticles; 0/ferumoxtran-10; K3R6ZDH4DU/Dextrans; S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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