| Cerebral blood perfusion and neurobehavioral performance in full-term small-for-gestational-age fetuses. | |
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MedLine Citation:
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PMID: 19631930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate changes in cerebral blood perfusion and middle cerebral artery (MCA) Doppler in full-term small-for-gestational-age fetuses (SGA) and to explore their association with neonatal neurobehavioral performance. STUDY DESIGN: Frontal brain perfusion that was measured by fractional moving blood volume (FMBV) and MCA Doppler pulsatility index were assessed in 60 SGA fetuses with normal umbilical artery Doppler results that were matched with adequate-for-gestational-age fetuses. Neonates were evaluated with the Neonatal-Behavioral-Assessment-Scale (NBAS). RESULTS: The proportion of SGA fetuses with increased FMBV (35% vs 5%; P < .001) and decreased MCA Doppler pulsatility index (15% vs 1.7%; P < .01) was significantly higher. SGA fetuses showed poorer NBAS scores in all areas. Increased FMBV identified SGA fetuses with the highest risks of abnormal NBAS in social-interactive (odds ratio, 7.8), attention (odds ratio, 22.8), and state-organization (odds ratio, 25.0). Abnormal MCA Doppler identified SGA with abnormal scores in motor area (odds ratio, 10.7). CONCLUSION: Increased brain blood perfusion discriminates SGA fetuses that are at risk for abnormal neurobehavior. |
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Authors:
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Rogelio Cruz-Martinez; Francesc Figueras; Daniel Oros; Nelly Padilla; Eva Meler; Edgar Hernandez-Andrade; Eduard Gratacos |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-24 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 201 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 474.e1-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Maternal-Fetal Medicine, Hospital Clinic-University of Barcelona, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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blood supply* Cerebrovascular Circulation Humans Infant, Newborn Infant, Small for Gestational Age* Middle Cerebral Artery / ultrasonography* Neuropsychological Tests Psychomotor Performance Term Birth Ultrasonography, Doppler |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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