Document Detail


Cerebral blood flow studies in the diagnosis and management of intrauterine growth restriction.
MedLine Citation:
PMID:  23354073     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To provide evidence that fetal brain vasodilatation can be related with postnatal cerebral structural and functional complications. RECENT FINDINGS: Most early-onset intrauterine growth restricted (IUGR) fetuses show signs of brain vasodilatation. As most of them are born prematurely, a high prevalence of short-term and long-term neurological complications is expected. However, the clinical significance of brain vasodilatation might be different. In the early stage of fetal deterioration, the risk of structural brain damage is low, but at advanced stages there is an increased risk of periventricular leukomalacia and intraventricular hemorrhage. The presence of brain vasodilatation in fetuses with an estimated fetal weight below the 10th centile but normal umbilical artery Doppler can be used to identify late-onset IUGR fetuses with latent placental insufficiency. These fetuses have an increased risk of abnormal neurological performance at birth and at 2 years of age. SUMMARY: Changes in cerebral brain blood perfusion in IUGR fetuses can be detected by Doppler ultrasound techniques. Despite its association with structural and functional neurological damage after birth, fetal brain vasodilatation is usually not considered in the decision to deliver, with the only exception of the 'return' to normal middle cerebral artery pulsatility index, which is highly associated with an increased risk for perinatal mortality.
Authors:
Edgar Hernandez-Andrade; Tamara Stampalija; Francesc Figueras
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  -     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Obstetrics and Gynecology, Hutzel Women's Hospital, Wayne State University, Detroit, Michigan, USA bNational Institute of Perinatology, Mexico City, Mexico cDepartment of Obstetrics and Gynecology Children's Hospital Vittore Buzzi, University of Milan, Milan, Italy dDepartment of Maternal-Fetal Medicine, Hospital Clínic, Universitat de Barcelona and Perinatal Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
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