| Cerebral blood flow and rheologic alterations by hyperosmolar therapy in patients with brain oedema. | |
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MedLine Citation:
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PMID: 2128575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral blood flow was assessed as initial slope index by 133-Xenon inhalation in 36 patients with brain tumours subjected to osmotic dehydration. The following solutions were employed: I. 20% mannitol, II. 40% sorbitol, III. 10% glycerol. Parameters affecting blood rheologic properties as Hct, plasma viscosity, red blood cell aggregation and fluidity were simultaneously studied. CBF which was reduced in the oedematous hemisphere with brain tumour increased during infusion and thereafter by mannitol or sorbitol, respectively. The blood flow response to glycerol was more delayed, less intense, but maintained longer. Hct and plasma viscosity were significantly reduced by all osmotic agents, while red blood cell fluidity fell and aggregation rose under mannitol. It is concluded that sorbitol (40%) is superior for emergency treatment with high ICP, whereas glycerol seems to be preferable to improve cerebral blood flow in oedematous brain. |
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Authors:
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A Hartmann; C Dettmers; H Schott; S Beyenburg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurochirurgica. Supplementum Volume: 51 ISSN: 0065-1419 ISO Abbreviation: Acta Neurochir Suppl (Wien) Publication Date: 1990 |
Date Detail:
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Created Date: 1991-05-24 Completed Date: 1991-05-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0140560 Medline TA: Acta Neurochir Suppl (Wien) Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 168-9 Citation Subset: IM |
Affiliation:
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Neurologische Universitäts-Klinik, Bonn, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cerebrovascular Circulation
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drug effects* Erythrocyte Aggregation / drug effects Erythrocyte Deformability / drug effects Glycerol / pharmacology* Humans Mannitol / pharmacology* Osmolar Concentration Rheology Sorbitol / pharmacology* |
| Chemical | |
Reg. No./Substance:
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50-70-4/Sorbitol; 56-81-5/Glycerol; 69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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