Document Detail

Cerebral blood flow and oxygen metabolism in infants with hydrocephalus.
MedLine Citation:
PMID:  1611609     Owner:  NLM     Status:  MEDLINE    
In this study, regional cerebral blood flow (rCBF) and the cerebral metabolic rate of oxygen (rCMRO2) were measured using positron emission tomography (PET) with oxygen-15 radiopharmaceuticals to clarify the pathophysiology of ventriculomegaly in the developing brain. Four hydrocephalic infants without severe neurological deficit were studied. Hypoperfusion was observed in the frontal, parietal, and visual association cortices which surrounded dilated anterior or posterior horns of the lateral ventricle. Lower rCMRO2 values than adult rates were observed in all cases. In the infants with markedly enlarged anterior or posterior horns, the surrounding cortices showed relatively lower rCMRO2 values with the fall of rCBF. Postoperative studies were performed in two infants. rCMRO2 increased in every region after ventriculoperitoneal shunting, but little change was observed in rCBF. These results indicate that metabolic deterioration occurs in the developing brain with hydrocephalus.
R Shirane; S Sato; K Sato; M Kameyama; A Ogawa; T Yoshimoto; J Hatazawa; M Ito
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  8     ISSN:  0256-7040     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-28     Completed Date:  1992-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  118-23     Citation Subset:  IM    
Division of Neurosurgery, Tohoku University, Sendai City, Japan.
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MeSH Terms
Blood Volume / physiology
Brain / blood supply*
Brain Damage, Chronic / radionuclide imaging
Cerebral Ventricles / radionuclide imaging
Energy Metabolism / physiology
Hydrocephalus / radionuclide imaging*
Infant, Newborn
Neurologic Examination
Oxygen Consumption / physiology*
Radiation Dosage
Regional Blood Flow / physiology
Tomography, Emission-Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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