Document Detail

Cerebral blood flow in preterm infants during the first week of life.
MedLine Citation:
PMID:  2420149     Owner:  NLM     Status:  MEDLINE    
Forty-two preterm infants of 28-33 weeks of gestation were studied once during the first week of life by 133-Xenon clearance after intravenous injection to estimate global cerebral blood flow. Count rates detected over the chest were corrected for chest wall contribution and used as arterial input function. A neonatal blood-brain partition coefficient of Xenon was used for the calculation of a mean flow estimator (CBF-infinity). The technique was internally validated by use of differently obtained arterial input functions. In 11 infants without respiratory distress, CBF-infinity was 19.8 ml/100 g/min +/- 5.3 SD. In 24 infants treated with mechanical ventilation CBF-infinity was 11.8 ml/100 g/min +/- 3.2 SD. In 7 infants treated with continuous positive airway pressure CBF-infinity was 21.3 ml/100 g/min +/- 12.0 SD. When the reduction of CBF-infinity associated with mechanical ventilation was taken into account, the 9 infants with subependymal/intraventricular haemorrhage had increased CBF-infinity. The effects of gestational age, birthweight, mode of delivery, postnatal age, mean arterial blood pressure, PaCO2, blood haemoglobin and phenobarbitone medication were also analysed and found inconsistent. In conclusion, CBF was lower than expected and in infants requiring mechanical ventilation the values were lower still.
G Greisen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  75     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-15     Completed Date:  1986-04-15     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
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MeSH Terms
Cerebrovascular Circulation*
Developmental Disabilities / etiology
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / physiopathology*
Respiration, Artificial
Vitamin K Deficiency Bleeding / physiopathology
Xenon Radioisotopes / diagnostic use
Reg. No./Substance:
0/Xenon Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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