| Cerebral blood flow in mean cerebral artery low density areas is not always ischemic in patients with aneurysmal subarachnoid hemorrhage--relationship with neurological outcome. | |
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MedLine Citation:
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PMID: 16463841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aneurysmal subarachnoid hemorrhage (SAH) can be complicated by reduction of regional cerebral blood flow (rCBF) from large conductance vessels leading to focal edema appearing as an area of hypoattenuation on CT. In this study we included 29 patients with SAH due to aneurysmal rupture, having 36 CT low density areas within the middle cerebral artery territory in whom a total of 56 Xenon-CT (Xe-CT) studies were performed. Collectively, we evaluated 70 hypoattenuated areas. rCBF levels were measured in two different regions of interest drawn manually on the CT scan, one in the low density area and the other in a corresponding contralateral area of normal-appearing brain tissue. In the low density area (22.6 +/- 22.7 ml/100 gr/min) rCBF levels were significantly lower than in the contralateral area (32.8 +/- 17.1 7 ml/100 gr/min) (p = 0.0007). In the injured areas deep ischemia (CBF < 6 ml/ 100 g/min) was present in only 25.7% of Xe-CT studies, suggesting that hypodense areas are not always ischemic, whereas in 43.7% of the lesions/Xe-CT studies we found hyperemic values. Patients with a better outcome had hyperemic lesions, suggesting brain tissue recovery in injured areas. |
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Authors:
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A Chieregato; F Tagliaferri; A Tanfani; F Cocciolo; W Benedettini; C Compagnone; M Ravaldini; R Pascarella; R Battaglia; M Frattarelli; L Targa; E Fainardi |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta neurochirurgica. Supplement Volume: 95 ISSN: 0065-1419 ISO Abbreviation: Acta Neurochir. Suppl. Publication Date: 2005 |
Date Detail:
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Created Date: 2006-02-08 Completed Date: 2006-03-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100962752 Medline TA: Acta Neurochir Suppl Country: Austria |
Other Details:
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Languages: eng Pagination: 153-8 Citation Subset: IM |
Affiliation:
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Neurorianimazione, Ospedale M. Bufalini, Cesena, Italy. achiere@ausl-cesena.emr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon
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statistics & numerical data Brain / blood supply*, radiography Brain Ischemia / mortality*, radiography* Cerebral Arterial Diseases / mortality*, radiography* Cerebrovascular Circulation Female Humans Italy / epidemiology Male Middle Aged Outcome Assessment (Health Care) Prevalence Prognosis Risk Assessment / methods Risk Factors Statistics as Topic Subarachnoid Hemorrhage / mortality*, radiography* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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