Document Detail


Cerebral blood flow and evoked potentials during reoxygenation with 21 or 100% O2 in newborn pigs.
MedLine Citation:
PMID:  8307859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of resuscitation with 21 or 100% O2 on cerebral blood flow (CBF) and somatosensory evoked potentials (SEPs) were studied in 19 newborn pigs anesthetized with pentobarbital sodium. They were ventilated with 8% O2 until base excess reached -20 mmol/l and then were randomly reoxygenated with 21% O2 (n = 10) or 100% O2 (n = 9) for 25 min followed by 21% O2. Mean duration of hypoxemia in the two groups was 57 +/- 6 (SE) and 59 +/- 6 min, respectively. CBF determined by radioactive microspheres was significantly increased in all areas in both groups after 5 and 20 min of reoxygenation. At 5 min of reoxygenation forebrain O2 uptake (CMRo2) had increased significantly compared with baseline values in the 21% O2 group (2.5 +/- 0.1 to 3.2 +/- 0.2 ml.100 g-1.min-1) but not in the 100% O2 group. There were, however, no significant differences between the two groups in CBF or CMRo2 at any time, and by 60 min of reoxygenation both had returned to baseline levels. SEPs were not significantly different in the two groups. We conclude that, as judged by CBF, CMRo2, and SEP, 21% O2 is not inferior to 100% O2 when hypoxemic newborn pigs are reoxygenated.
Authors:
T Rootwelt; J P Odden; C Hall; T Ganes; O D Saugstad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-17     Completed Date:  1994-03-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2054-60     Citation Subset:  IM    
Affiliation:
Institute for Surgical Research, Department of Pediatric Research, University of Oslo, Norway.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Anoxia / physiopathology
Blood Gas Analysis
Blood Pressure / drug effects
Cerebrovascular Circulation / drug effects,  physiology*
Evoked Potentials, Somatosensory / drug effects,  physiology*
Hemodynamics / drug effects
Microspheres
Oxygen / pharmacology*
Oxygen Consumption / drug effects,  physiology
Resuscitation
Swine
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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