| Cerebral blood flow during exercise: mechanisms of regulation. | |
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MedLine Citation:
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PMID: 19729591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The response of cerebral vasculature to exercise is different from other peripheral vasculature; it has a small vascular bed and is strongly regulated by cerebral autoregulation and the partial pressure of arterial carbon dioxide (Pa(CO(2))). In contrast to other organs, the traditional thinking is that total cerebral blood flow (CBF) remains relatively constant and is largely unaffected by a variety of conditions, including those imposed during exercise. Recent research, however, indicates that cerebral neuronal activity and metabolism drive an increase in CBF during exercise. Increases in exercise intensity up to approximately 60% of maximal oxygen uptake produce elevations in CBF, after which CBF decreases toward baseline values because of lower Pa(CO(2)) via hyperventilation-induced cerebral vasoconstriction. This finding indicates that, during heavy exercise, CBF decreases despite the cerebral metabolic demand. In contrast, this reduced CBF during heavy exercise lowers cerebral oxygenation and therefore may act as an independent influence on central fatigue. In this review, we highlight methodological considerations relevant for the assessment of CBF and then summarize the integrative mechanisms underlying the regulation of CBF at rest and during exercise. In addition, we examine how CBF regulation during exercise is altered by exercise training, hypoxia, and aging and suggest avenues for future research. |
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Authors:
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Shigehiko Ogoh; Philip N Ainslie |
Publication Detail:
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Type: Journal Article; Review Date: 2009-09-03 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 107 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-05 Completed Date: 2010-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1370-80 Citation Subset: IM |
Affiliation:
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Dept. of Biomedical Engineering, Toyo Univ., 2100 Kujirai, Kawagoe-shi, Saitama 350-8585, Japan. ogoh@toyonet.toyo.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology* Cerebrovascular Circulation / physiology* Exercise / physiology* Feedback, Physiological / physiology Humans Muscle Contraction / physiology* Muscle, Skeletal / physiology* Oxygen Consumption / physiology* |
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