Document Detail


Cerebral blood flow and cognitive responses to rivastigmine treatment in Alzheimer's disease.
MedLine Citation:
PMID:  11924899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty seven patients with mild AD were enrolled in a prospective open label controlled study of rivastigmine. Assessments included a range of neuropsychiatric and behavioural measures and rCBF using HMPAO SPECTat baseline, three and six months. Significant enhancement of frontal, parietal and temporal brain blood flow with related psychometric improvement was observed in twelve of the treated patients. A pattern of reduced rCBF and cognitive performance was observed in four unresponsive and eleven untreated patients. The results suggest that alterations in the clinical and cognitive status of patients receiving a cholinesterase inhibitor are paralleled by changes in rCBF. Longitudinal assessment with repeated imaging offers a method of better understanding the effects of cholinesterase inhibition on the AD brain.
Authors:
Annalena Venneri; Michael F Shanks; Roger T Staff; Simon J Pestell; Katrina E Forbes; Howard G Gemmell; Alison D Murray
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  13     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-04-01     Completed Date:  2002-07-18     Revised Date:  2009-02-11    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Aberdeen, UK.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / drug therapy*,  physiopathology,  psychology
Carbamates / therapeutic use*
Cerebrovascular Circulation / drug effects*
Cholinesterase Inhibitors / therapeutic use*
Cluster Analysis
Cognition / drug effects*
Female
Humans
Longitudinal Studies
Male
Neuropsychological Tests
Phenylcarbamates*
Prospective Studies
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Exametazime / diagnostic use
Time Factors
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Carbamates; 0/Cholinesterase Inhibitors; 0/Phenylcarbamates; 0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime; 123441-03-2/rivastigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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