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Cerebral blood flow assessed by brain SPECT with 99mTc-HMPAO utilising the acetazolamide test in systemic lupus erythematosus.
MedLine Citation:
PMID:  14601004     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Cerebrovascular diseases are one of the most important complications of systemic lupus erythematosus (SLE). The diagnostic imaging of neuropsychiatric SLE complications presents many problems. This study was undertaken to investigate cerebral blood flow char s and its reactivity to hypercapnia by means of acetazolamide test in SLE patients.
METHODS: Brain SPELT studies using 99mTc-HMPAO were performed in 50 patients with SLE. Acetazolamide test was performed in 35 patients 3 days after the baseline study by means of repetitive scanning 20 min after i.v. injection of 1.0 g of acetazolamide.
RESULTS: Significant interhemispheric hypoperfusion areas were shown in 76.3% of all patients, 83.8% symptomatic and 63.1 % asymptomatic. Patients with antiphospholipid syndrome showed multifocal perfusion deficits. The reaction of cerebral perfusion to acetazolamide was heterogenous and showed increase, decrease, no change or mixed reaction of baseline-study-found focal hypoperfusion. Acetazolamide test revealed hypoperfusion in two patients with normal baseline study. MRI scanning revealed cerebral lesions in 41 % of patients.
CONCLUSIONS: CBF asymmetries in symptomatic and asymptomatic patients with SLE are frequent. Regional CBF alterations seem to be different in patients with and without antiphospholipid syndrome. The part of the patients with SLE shows no or paradoxically inversed reaction to acetazolamide.
P Lass; M Koseda; G Romanowicz; J Mechlińska; Z Banecka; M Góra; M Hebanowski; E Stepień; P Łyczak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine review. Central & Eastern Europe     Volume:  1     ISSN:  1506-9680     ISO Abbreviation:  Nucl Med Rev Cent East Eur     Publication Date:  1998  
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-01-13     Revised Date:  2011-10-13    
Medline Journal Info:
Nlm Unique ID:  100886103     Medline TA:  Nucl Med Rev Cent East Eur     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  -    
Department of Nuclear Medicine, Medical University, Gdańsk, Poland.
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