Document Detail

Cerebral blood flow, PaCO2 changes, and visual evoked potentials in mechanically ventilated, preterm infants.
MedLine Citation:
PMID:  3604659     Owner:  NLM     Status:  MEDLINE    
Two estimations of global cerebral blood flow (CBF) using 133-Xenon clearance were done with an interval of about one hour in 16 mechanically ventilated, newborn infants, of less than 33 weeks gestational age. In eight infants CBF was estimated just before a change in ventilator settings, and again when the PaCO2 was stable. In the remaining eight infants small spontaneous changes in PaCO2 occurred. The CBF-CO2 reactivity was similar in the two groups (+67%/kPa (95% confidence interval 13-146) and 52%/kPa (24-86)) and considerably higher than the CBF-CO2 reactivity estimated from the interindividual variation of flow and PaCO2 (+19%/kPa (4-36)). There were no significant relations between CBF and arterial blood pressure. Flash evoked potentials (VEP) were recorded during the 133-Xenon clearances in 8 of the infants. VEP showed no relation to changes in CBF, even when the blood flow rose from the lowest levels. CBF and VEP were obtained once in 9 other infants. Among the 17 infants, the latency of the first negative wave of the VEP was not related to the CBF level. Mean CBF in the 25 infants was 12.3 ml/100 g/min (range 4.3 to 18.9), mean PaCO2 was 4.2 kPa (range 2.3 to 6.4). Thus, CBF-CO2 reactivity appeared to be normal in these clinically stable, mechanically ventilated, preterm infants, suggesting that their low cerebral blood flow was well regulated. The absence of a relation of CBF with VEP suggested that cerebral blood flow was not critically decreased.
G Greisen; W Trojaborg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  76     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-11     Completed Date:  1987-08-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  394-400     Citation Subset:  IM    
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MeSH Terms
Blood Gas Monitoring, Transcutaneous
Cerebrovascular Circulation*
Evoked Potentials, Visual*
Infant, Newborn
Infant, Premature / physiology*
Respiration, Artificial*

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