| Cerebral β-amyloid detected by Pittsburgh compound B positron emission topography predisposes to recombinant tissue plasminogen activator-related hemorrhage. | |
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MedLine Citation:
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PMID: 20661925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue-type plasminogen activator (rt-PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral β-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, suggesting underlying CAA as a predisposing factor for rt-PA-related hemorrhage. This finding may provide an impetus for the development of a more practical rapid pretreatment screening technique. |
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Authors:
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John V Ly; Christopher C Rowe; Victor L Villemagne; Jorge A Zavala; Henry Ma; Graeme O'Keefe; Sylvia J Gong; Rico Gunawan; Leonid Churilov; Tim Saunder; Uwe Ackerman; Henri Tochon-Danguy; Geoffrey A Donnan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of neurology Volume: 68 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-01-03 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 959-62 Citation Subset: IM |
Affiliation:
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National Stroke Research Institute, Austin Health, University of Melbourne, Heidelberg Heights, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Benzothiazoles / diagnostic use* Cerebral Amyloid Angiopathy / etiology, radionuclide imaging* Female Fibrinolytic Agents / adverse effects* Hemorrhage / chemically induced*, complications* Humans Magnetic Resonance Imaging / methods Male Positron-Emission Tomography / methods ROC Curve Retrospective Studies Stroke / drug therapy Tissue Plasminogen Activator / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Benzothiazoles; 0/Fibrinolytic Agents; 0/N-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole; EC 3.4.21.68/Tissue Plasminogen Activator |
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