Document Detail


Cerebral β-amyloid detected by Pittsburgh compound B positron emission topography predisposes to recombinant tissue plasminogen activator-related hemorrhage.
MedLine Citation:
PMID:  20661925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue-type plasminogen activator (rt-PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral β-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, suggesting underlying CAA as a predisposing factor for rt-PA-related hemorrhage. This finding may provide an impetus for the development of a more practical rapid pretreatment screening technique.
Authors:
John V Ly; Christopher C Rowe; Victor L Villemagne; Jorge A Zavala; Henry Ma; Graeme O'Keefe; Sylvia J Gong; Rico Gunawan; Leonid Churilov; Tim Saunder; Uwe Ackerman; Henri Tochon-Danguy; Geoffrey A Donnan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  68     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  959-62     Citation Subset:  IM    
Affiliation:
National Stroke Research Institute, Austin Health, University of Melbourne, Heidelberg Heights, Australia.
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MeSH Terms
Descriptor/Qualifier:
Aged
Benzothiazoles / diagnostic use*
Cerebral Amyloid Angiopathy / etiology,  radionuclide imaging*
Female
Fibrinolytic Agents / adverse effects*
Hemorrhage / chemically induced*,  complications*
Humans
Magnetic Resonance Imaging / methods
Male
Positron-Emission Tomography / methods
ROC Curve
Retrospective Studies
Stroke / drug therapy
Tissue Plasminogen Activator / adverse effects*
Chemical
Reg. No./Substance:
0/Benzothiazoles; 0/Fibrinolytic Agents; 0/N-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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