Document Detail

Cerebral atrophy and long-term response to levodopa in Parkinson's disease.
MedLine Citation:
PMID:  93625     Owner:  NLM     Status:  MEDLINE    
In 92 parkinsonian patients (42 men, 50 women) aged from 37-79 years (mean 62.8) the impact of cerebral atrophy as assessed by computed tomography on the course of the clinical symptomatology under levodopa during a period of 1 to 5 years was investigated. It could be shown that patients suffering from medium to severe degrees of atrophy-independent of its special location--have a less favorable response than those with normal CT findings. The data do not allow a definite decision whether cortical artrophy or ventricular enlargement are of major importance. At any rate, the width of the third ventricle seems to have no influence on the course of the clinical symptoms. After 3 years of levodopa treatment a dissociation between cerebral atrophy and therapeutic effectiveness can be observed.
E Schneider; P A Fischer; P Jacobi; H Becker; M Beyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  222     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1979  
Date Detail:
Created Date:  1980-04-17     Completed Date:  1980-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
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MeSH Terms
Brain / pathology*
Cerebral Cortex / pathology,  radiography
Cerebral Ventricles / pathology
Follow-Up Studies
Levodopa / therapeutic use*
Middle Aged
Parkinson Disease / drug therapy*
Time Factors
Tomography, X-Ray Computed
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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