| Cerebral aspergillosis in an infant with corticosteroid-resistant nephrotic syndrome. | |
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MedLine Citation:
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PMID: 12736806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral aspergillosis is a devastating disease in patients with a compromised immune system. A unique case of a male infant with corticosteroid-resistant nephrotic syndrome complicated by pulmonary and cerebral aspergillosis is described. The patient rapidly developed coma and neurological symptoms and died soon thereafter. Central nervous system aspergillosis was diagnosed radiologically and by detection of Aspergillus DNA and antigen (galactomannan) in blood and cerebrospinal fluid. Moderate immunosuppressive therapy and antifungal phagocytic dysfunction due to nephrotic syndrome per se may have contributed to the occurrence of invasive aspergillosis in our patient. Awareness of this serious complication and early application of diagnostic procedures and antifungal therapy may improve the dismal outcome. |
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Authors:
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Emmanuel Roilides; Efterpi Pavlidou; Frantzis Papadopoulos; Christos Panteliadis; Evangelia Farmaki; Maria Tamiolaki; John Sotiriou |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2003-03-18 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 18 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-08 Completed Date: 2004-01-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 450-3 Citation Subset: IM |
Affiliation:
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3rd Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece. roilides@med.auth.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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adverse effects* Aspergillus fumigatus* / isolation & purification Drug Resistance Fatal Outcome Humans Immunocompromised Host Infant Male Nephrotic Syndrome / complications*, drug therapy*, immunology Neuroaspergillosis / etiology*, immunology, radiography Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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