Document Detail

Cerebral arteriovenous malformations: issues of the interplay between stereotactic radiosurgery and endovascular surgical therapy.
MedLine Citation:
PMID:  21704930     Owner:  NLM     Status:  In-Data-Review    
Intracranial arteriovenous malformations (AVMs) are congenital lesions frequently diagnosed as a result of hemorrhage or other neurological symptoms. Prevention of such devastating neurological injury has promoted a variety of treatment strategies. The rich history of multimodal therapy in the treatment of AVMs includes microsurgery, endovascular embolization, and stereotactic radiosurgery (SRS). This article reviews the biology and natural history of AVMs, as well as their treatment with both SRS and endovascular neurosurgery. It considers various paradigms and goals of endovascular treatment, along with relevant issues such as the features of an AVM to be targeted. Issues of the interplay between SRS and endovascular neurosurgery include the compartments of an embolized AVM to contain within the radiosurgery plan, the radioprotective and radiosensitizing effects of the embolic agent, the durability of embolization, and the sequencing of embolization with respect to the radiosurgical treatment. Published literature on these topics is sparse, and the flimsiness of the data offers limited guidance.
Parham Yashar; Arun P Amar; Steven L Giannotta; Cheng Yu; Paul G Pagnini; Charles Y Liu; Michael L J Apuzzo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World neurosurgery     Volume:  75     ISSN:  1878-8750     ISO Abbreviation:  World Neurosurg     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528275     Medline TA:  World Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  638-47     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
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