Document Detail


Cerebral arteriovenous malformations. Part 2: physiology.
MedLine Citation:
PMID:  19408989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: The scientific understanding of the nature of arteriovenous malformations (AVMs) in the brain is evolving. It is clear from current work that AVMs can undergo a variety of phenomena, including growth, remodeling, and/or regression-and the responsible processes are both molecular and physiological. A review of these complex processes is critical to directing future therapeutic approaches. The authors performed a comprehensive review of the literature to evaluate current information regarding the genetics, pathophysiology, and behavior of AVMs. METHODS: A comprehensive literature review was conducted using PubMed to reveal the angioarchitecture and cerebral hemodynamics of AVMS as they relate to lesion development. RESULTS: Feeding artery pressures, brain AVM compartmentalization, venous drainage, flow phenomena, and vascular steal are discussed. CONCLUSIONS: The dynamic nature of brain AVMs is at least in part attributable to hemodynamic and flow-related phenomena. These forces acting on an evolving structure are critical to understanding the challenges in endovascular and surgical therapy. As knowledge in this field continues to progress, the natural history and predicted behavior of these AVMs will become more clearly elucidated.
Authors:
Parham Moftakhar; Jason S Hauptman; Dennis Malkasian; Neil A Martin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgical focus     Volume:  26     ISSN:  1092-0684     ISO Abbreviation:  Neurosurg Focus     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896471     Medline TA:  Neurosurg Focus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E11     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Cedars Sinai Medical Center, University of California, Los Angeles, California 90095, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Brain / blood supply,  physiopathology
Capillaries / pathology,  physiopathology
Cerebral Arteries / abnormalities*,  metabolism,  physiopathology*
Cerebral Veins / abnormalities*,  metabolism,  physiopathology*
Cerebrovascular Circulation / genetics*
Hemodynamics / genetics
Humans
Intracranial Aneurysm / etiology,  physiopathology
Intracranial Arteriovenous Malformations / complications,  genetics,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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