Document Detail


Cerebral arteriopathy with extracranial artery involvement in a patient with ulcerative colitis.
MedLine Citation:
PMID:  16364366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arteriopathy of the central nervous system (CNS) complicated with ulcerative colitis is a rare condition, moreover the involvement of extracranial arteries has not been documented. An 18-year-old female complained of a severe pulsatile headache and nausea. She had been diagnosed and treated for ulcerative colitis for four years. Magnetic resonance imaging of the brain showed normal results; however, magnetic resonance angiography (MRA) revealed severe irregularity of the intracerebral arteries. After treatment with prednisolone, the patient fully recovered and the irregularity of the intracerebral arteries was dramatically improved. Vasculitis was strongly suggested as the cause of arteriopathy of the CNS in the present case. Involvement of extracranial arteries such as the carotid artery was also incidentally discovered by duplex ultrasonography and the HLA typing suggested genetic susceptibility to Takayasu's arteritis. Findings from our patient suggest that extracranial arterial involvement should be considered in the case of arteriopathy of the CNS associated with ulcerative colitis.
Authors:
Tatsuya Nomoto; Takehiko Nagao; Kyugo Hirabayashi; Takehiro Seta; Masayuki Yokochi; Ken-ichiro Katsura; Yasuo Katayama
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-12-20
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  243     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-06-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  87-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Tokyo Metropolitan Ebara Hospital, Tokyo 145-0065, Japan. nomotatsu@jichi.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anti-Inflammatory Agents / therapeutic use
Carotid Artery Diseases / drug therapy,  radiography,  ultrasonography
Carotid Artery, External / pathology,  physiopathology,  radiography
Cerebral Angiography
Cerebral Arteries / pathology*,  physiopathology*,  radiography
Colitis, Ulcerative / complications*
Female
Genetic Predisposition to Disease / genetics
HLA Antigens / genetics,  immunology
Humans
Magnetic Resonance Angiography
Prednisolone / therapeutic use
Takayasu Arteritis / diagnosis,  drug therapy,  genetics
Vasculitis, Central Nervous System / complications*,  diagnosis*,  drug therapy
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/HLA Antigens; 50-24-8/Prednisolone

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