| Cerebral arteriolar thromboembolism in idiopathic hypereosinophilic syndrome. | |
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MedLine Citation:
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PMID: 19364940 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe imaging findings as well as postmortem brain and cardiac pathology in a patient with fulminant idiopathic hypereosinophilic syndrome. DESIGN: Case report. SETTING: University hospital. PATIENT: A 48-year-old right-handed man with hypereosinophilia, rapidly progressive encephalopathy, and focal neurological deficits who died 22 days after presentation. MAIN OUTCOME MEASURES: Physical examination, radiologic, and neuropathologic examination results. RESULTS: Imaging of the brain revealed bihemispheric ischemic changes in and beyond the watershed distributions. Pathology review demonstrated mural cardiac thrombus that likely caused cardioembolism as well as diffuse microangiopathy despite resolution of the hypereosinophilia. CONCLUSIONS: Timely recognition of idiopathic hypereosinophilic syndrome may enable aggressive treatment prior to widespread cardioembolism and degranulation that result in devastating cerebrovascular complications. |
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Authors:
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Mikayel Grigoryan; Scott D Geisler; Erik K St Louis; Gary L Baumbach; Patricia H Davis |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of neurology Volume: 66 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-14 Completed Date: 2009-04-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 528-31 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242, USA. mikayel-grigoryan@uiowa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anterior Cerebral Artery
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pathology Arterioles / pathology Bone Marrow / pathology Brain / pathology Diagnosis, Differential Diffusion Magnetic Resonance Imaging* Dominance, Cerebral / physiology Echocardiography, Transesophageal Endocardium / pathology Fatal Outcome Heart Diseases / complications, diagnosis, pathology Humans Hypereosinophilic Syndrome / complications*, diagnosis, pathology Image Processing, Computer-Assisted* Infarction, Anterior Cerebral Artery / diagnosis*, pathology Male Middle Aged Thrombosis / complications, diagnosis, pathology Tomography, X-Ray Computed* |
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