| Cerebral amyloid angiopathy with severe secondary vascular pathology: a histopathological study. | |
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MedLine Citation:
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PMID: 16179828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral amyloid angiopathy (CAA) is a common neuropathological finding and is characterized by deposition of fibrillar amyloid in cortical and leptomeningeal vessels. In this study we describe the macroscopic and microscopic neuropathological findings of 5 patients with severe CAA-associated secondary vascular changes, including smooth muscle cell degeneration, hyalinization, 'double-barreling' phenomenon, macrophage infiltration, and aneurysmal dilatation of the vessel wall. In 3 of the 5 patients these vascular changes were associated with multiple small hemorrhages, whereas in 2 patients areas of ischemic necrosis were observed. However, none of these patients suffered from large (lobar) hemorrhagic accidents. Nevertheless, severe CAA, particularly when associated with secondary vascular pathology, may lead to vascular dementia-like ischemic changes. Hence, the distinction between patients with severe CAA and secondary vascular abnormalities from those suffering from vascular dementia can be difficult. We speculate that CAA, particularly when associated with secondary vascular pathology, although not resulting in large hemorrhages, may contribute to cognitive decline. The functional impact of CAA and CAA-related secondary vascular changes on cognitive performance warrants further exploration. |
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Authors:
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Jack van Horssen; Danielle de Jong; Robert M W de Waal; Cathy Maass; Irene Otte-Holler; Berry Kremer; Marcel M Verbeek; Pieter Wesseling |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-22 |
Journal Detail:
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Title: Dementia and geriatric cognitive disorders Volume: 20 ISSN: 1420-8008 ISO Abbreviation: Dement Geriatr Cogn Disord Publication Date: 2005 |
Date Detail:
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Created Date: 2005-10-12 Completed Date: 2005-12-01 Revised Date: 2008-03-24 |
Medline Journal Info:
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Nlm Unique ID: 9705200 Medline TA: Dement Geriatr Cogn Disord Country: Switzerland |
Other Details:
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Languages: eng Pagination: 321-30 Citation Subset: IM |
Affiliation:
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Department of Pathology, University Medical Center, Nijmegen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Amyloid beta-Protein / metabolism Amyloid beta-Protein Precursor / genetics Apolipoproteins E / genetics Cerebral Amyloid Angiopathy / genetics, pathology* Cerebral Arteries / pathology Cerebrovascular Circulation / physiology* Female Humans Immunohistochemistry Inflammation / pathology Male Neurodegenerative Diseases / pathology Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Amyloid beta-Protein Precursor; 0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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