Document Detail


Cerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly.
MedLine Citation:
PMID:  8336159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated consecutive 1000 autopsied cases (average age 82.9 years) clinicopathologically in order to reveal the significance of cerebral amyloid angiopathy (CAA) as a cause of senile intracranial hemorrhages. We found 101 cases with intracerebral hemorrhages, and CAA accounted for 10.9% of them (31.0% of lobar cerebral hemorrhages, and 14.3% of cerebellar ones). In contrast to hypertensive hemorrhages, CAA-related ones (1) ruptured into the subarachnoid space without exception, (2) often coexisted with dementia of Alzheimer's type, and (3) frequently occurred in the night without elevated blood pressure at onset. The cerebrovascular amyloid was strongly immunoreactive with antibody to beta-protein in all of the cases with CAA-related hemorrhages, and less intensively with antibody to cystatin C in 91% of them. Our data indicate that CAA is an important etiological factor of cerebellar hemorrhages, as well as lobar cerebral hemorrhages, in normotensive, aged patients.
Authors:
Y Itoh; M Yamada; M Hayakawa; E Otomo; T Miyatake
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  116     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-20     Completed Date:  1993-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-41     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Yokufukai Geriatric Hospital, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / pathology
Amyloid beta-Protein / immunology,  metabolism
Arteriosclerosis / pathology
Blood Pressure / physiology
Brain Stem / pathology
Cerebellar Diseases / etiology*,  pathology
Cerebral Amyloid Angiopathy / complications*,  pathology
Cerebral Hemorrhage / etiology*,  pathology
Female
Humans
Hypertension / complications
Immunohistochemistry
Male
Middle Aged
Subarachnoid Hemorrhage / pathology
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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