| Cerebral amyloid angiopathy-related hemorrhage in a middle-aged patient with Down's syndrome. | |
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MedLine Citation:
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PMID: 19065301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A patient with Down's syndrome (DS) died of cerebral hemorrhage at age 52. At autopsy, a large sub-cortical hematoma was present in the right frontal lobe, and microscopic examination showed numerous senile plaques and neurofibrillary tangles in an extensive area of neocortex and also disclosed heavy involvement of vascular walls by amyloid deposition. These senile plaque and vascular amyloid deposits were specifically stained with an antibody to Abeta. His APOE genotype was epsilon4/epsilon4. This is a rare case of DS with cerebral amyloid angiopathy (CAA)-related cerebral hemorrhage. Genetic factors, such as APOE genotype, conceivably determine the risk of vascular rupture in individuals with CAA, even among patients with DS. |
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Authors:
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Ko-Suke Naito; Yoshiki Sekijima; Shu-Ichi Ikeda |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Volume: 15 ISSN: 1744-2818 ISO Abbreviation: Amyloid Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-09 Completed Date: 2009-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433802 Medline TA: Amyloid Country: United States |
Other Details:
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Languages: eng Pagination: 275-7 Citation Subset: IM |
Affiliation:
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Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan. tamame@aurora.ocn.ne.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyloid beta-Protein
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genetics Apolipoproteins E / genetics Cerebral Amyloid Angiopathy, Familial / complications*, genetics, pathology Cerebral Hemorrhage / etiology*, pathology Down Syndrome / complications*, genetics, pathology Genotype Humans Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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