Document Detail


Cerebral activation during motor imagery in complex regional pain syndrome type 1 with dystonia.
MedLine Citation:
PMID:  17561345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathogenesis of dystonia in Complex Regional Pain Syndrome type 1 (CRPS-1) is unclear. In primary dystonia, functional magnetic resonance imaging (fMRI) has revealed changes in cerebral networks during execution of movement. The aim of this study was to determine cerebral network function in CRPS-1 patients with dystonic postures. Cerebral processing related to both execution and imagining of hand movements in patients and controls was assessed with fMRI. Eight CRPS-1 patients with dystonic postures of the right upper extremity and 17 age-matched healthy controls were studied. Compared with controls, imaginary movement of the affected hand in patients showed reduced activation ipsilaterally in the premotor and adjacent prefrontal cortex, and in a cluster comprising frontal operculum, the anterior part of the insular cortex and the superior temporal gyrus. Contralaterally, reduced activation was seen in the inferior parietal and adjacent primary sensory cortex. There were no differences between patients and controls when they executed movements, nor when they imagined moving their unaffected hand. The altered cerebral activation pattern in patients with CRPS-1 linked dystonia most likely reflects an interface between pain-associated circuitry and higher order motor control, which points at a specific mechanistic pathophysiology of this type of dystonia.
Authors:
Esther W Gieteling; Monique A van Rijn; Bauke M de Jong; Johannes M Hoogduin; Remco Renken; Jacobus J van Hilten; Klaus L Leenders
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-11
Journal Detail:
Title:  Pain     Volume:  134     ISSN:  1872-6623     ISO Abbreviation:  Pain     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  302-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. e.w.gieteling@neuro.umcg.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / physiopathology*
Causalgia / physiopathology*
Dystonia / physiopathology*
Evoked Potentials, Motor*
Female
Humans
Imagination*
Male
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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