Document Detail

Cerebral abscess caused by Serratia marcescens in a premature neonate.
MedLine Citation:
PMID:  18094868     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cerebral abscesses are extremely rare in neonates. Serratia marcescens is an unusual cause of sepsis and neurological spread is especially ominous. PURPOSE: To report the case of a 34-week neonate who developed this rare condition and to discuss diagnostic and therapeutic measures. CASE REPORT: A 34-week male neonate sequentially developed respiratory distress syndrome, early sepsis and necrotizing enterocolitis; later cultures revealed S. marcescens. After deterioration, a cerebral abscess became evident, which revealed S. marcescens. Clinical improvement ensued after high-dose amikacin and meropenem. CONCLUSION: Clinical signs are often non-specific. Proper diagnostic measures, neurosurgical consultation and aggressive antibiotic therapy are essential for these high-risk neonates.
Tatiana Mattos Hirooka; Ricardo Braganca de Vasconcellos Fontes; Edna Maria Diniz; Fernando Campos Pinto; Hamilton Matushita
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  65     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-20     Completed Date:  2008-06-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1018-21     Citation Subset:  IM    
Department of Pediatrics, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
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MeSH Terms
Amikacin / therapeutic use
Anti-Bacterial Agents / therapeutic use
Brain Abscess / diagnosis,  drug therapy,  microbiology*
Diseases in Twins / diagnosis,  drug therapy,  microbiology*
Infant, Newborn
Serratia Infections / diagnosis,  drug therapy,  microbiology*
Serratia marcescens*
Thienamycins / therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Thienamycins; 37517-28-5/Amikacin; 96036-03-2/meropenem

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