Document Detail

Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia.
MedLine Citation:
PMID:  21071591     Owner:  NLM     Status:  MEDLINE    
The cerebral circulation has a central role in mediating the neurological complications of eclampsia, yet our understanding of how pregnancy and preeclampsia affect this circulation is severely limited. Here, we show that pregnancy causes outward remodeling of penetrating arterioles and increased capillary density in the brain due to activation of peroxisome proliferator-activated receptor-γ (PPARγ), a transcription factor involved in cerebrovascular remodeling and highly activated in pregnancy. Pregnancy-induced PPARγ activation also significantly affected cerebral hemodynamics, decreasing vascular resistance and increasing cerebral blood flow by ∼40% in response to acute hypertension that caused breakthrough of autoregulation. These structural and hemodynamic changes in the brain during pregnancy were associated with substantially increased blood-brain barrier permeability, an effect that could promote passage of damaging proteins into the brain and cause the neurological complications of eclampsia, including seizure.
Marilyn J Cipolla; Julie G Sweet; Siu-Lung Chan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-11
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  110     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-09     Completed Date:  2011-06-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-39     Citation Subset:  IM    
Department of Neurology, Univ. of Vermont, 89 Beaumont Ave., Given C454, Burlington, VT 05405, USA.
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MeSH Terms
Blood Flow Velocity
Cerebral Arteries / physiopathology*
Cerebrovascular Circulation*
Cerebrovascular Disorders / complications,  physiopathology*
Eclampsia / physiopathology*
Nervous System Diseases / complications,  physiopathology*
Pre-Eclampsia / physiopathology*
Rats, Sprague-Dawley
Vascular Resistance
Grant Support
NS045940/NS/NINDS NIH HHS; NS045940-05S1/NS/NINDS NIH HHS; R01 NS045940/NS/NINDS NIH HHS; R01 NS045940-05A2/NS/NINDS NIH HHS; R01 NS045940-05A2S1/NS/NINDS NIH HHS; R01 NS045940-06/NS/NINDS NIH HHS; R01 NS045940-07/NS/NINDS NIH HHS; R01 NS045940-08/NS/NINDS NIH HHS
Comment In:
J Appl Physiol (1985). 2011 Feb;110(2):305-6   [PMID:  21109599 ]

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