| Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia. | |
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MedLine Citation:
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PMID: 21071591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cerebral circulation has a central role in mediating the neurological complications of eclampsia, yet our understanding of how pregnancy and preeclampsia affect this circulation is severely limited. Here, we show that pregnancy causes outward remodeling of penetrating arterioles and increased capillary density in the brain due to activation of peroxisome proliferator-activated receptor-γ (PPARγ), a transcription factor involved in cerebrovascular remodeling and highly activated in pregnancy. Pregnancy-induced PPARγ activation also significantly affected cerebral hemodynamics, decreasing vascular resistance and increasing cerebral blood flow by ∼40% in response to acute hypertension that caused breakthrough of autoregulation. These structural and hemodynamic changes in the brain during pregnancy were associated with substantially increased blood-brain barrier permeability, an effect that could promote passage of damaging proteins into the brain and cause the neurological complications of eclampsia, including seizure. |
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Authors:
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Marilyn J Cipolla; Julie G Sweet; Siu-Lung Chan |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-11-11 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 110 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-09 Completed Date: 2011-06-07 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 329-39 Citation Subset: IM |
Affiliation:
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Department of Neurology, Univ. of Vermont, 89 Beaumont Ave., Given C454, Burlington, VT 05405, USA. Marilyn.Cipolla@uvm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Cerebral Arteries / physiopathology* Cerebrovascular Circulation* Cerebrovascular Disorders / complications, physiopathology* Eclampsia / physiopathology* Female Nervous System Diseases / complications, physiopathology* Pre-Eclampsia / physiopathology* Pregnancy Rats Rats, Sprague-Dawley Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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NS045940/NS/NINDS NIH HHS; NS045940-05S1/NS/NINDS NIH HHS; R01 NS045940-05A2/NS/NINDS NIH HHS; R01 NS045940-05A2S1/NS/NINDS NIH HHS; R01 NS045940-06/NS/NINDS NIH HHS; R01 NS045940-07/NS/NINDS NIH HHS; R01 NS045940-08/NS/NINDS NIH HHS |
| Comments/Corrections | |
Comment In:
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J Appl Physiol. 2011 Feb;110(2):305-6
[PMID:
21109599
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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