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Cerebral Oxygenation in Very Low Birth Weight Infants supported with Sustained Lung Inflations after Birth.
MedLine Citation:
PMID:  21522035     Owner:  NLM     Status:  Publisher    
Sustained lung inflations (SI's) immediately after birth might decrease the need for subsequent mechanical ventilation in preterm infants. However, effects of SI's on oxygenation and hemodynamics are undetermined. Our aim was to study immediate effects of SI's on heart rate, arterial oxygen saturation and cerebral tissue oxygen saturation in preterm infants supported with SI's after birth for lung recruitment. Heart rate, arterial oxygen saturation and cerebral tissue oxygen saturation using near infrared spectroscopy was measured in 24 preterm infants of 28.0 (26.6;29.3) weeks GA [median (interquartile range)] during resuscitation using up to three SI's of 20, 25 and 30 cm H2O of 15 sec duration each followed by nasal continuous positive airway pressure (CPAP) as first line approach for respiratory support. During positioning and suctioning immediately after delivery infants became progressively hypoxemic and bradycardic before respiratory support was initiated. In 18 infants (75%) more than one SI were applied. During the last SI's there was a rapid increase in the infants' heart rate and an increase in cerebral tissue oxygen saturation. Arterial saturation increased with slight delay. In conclusion effective last sustained inflations increase heart rate and cerebral tissue oxygen saturation to be followed by an increase in arterial saturation. ABBREVIATIONS::
Hans Fuchs; Wolfgang Lindner; Anja Buschko; Theresa Trischberger; Manuel Schmid; Helmut D Hummler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-25
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Ulm, Ulm, 89070, Germany.
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