| Cerebral microvascular disease predicts renal failure in type 2 diabetes. | |
| | |
MedLine Citation:
|
PMID: 20110380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Abnormalities in small renal vessels may increase the risk of developing impaired renal function, but methods to assess these vessels are extremely limited. We hypothesized that the presence of small vessel disease in the brain, which manifests as silent cerebral infarction (SCI), may predict the progression of kidney disease in patients with type 2 diabetes. We recruited 608 patients with type 2 diabetes without apparent cerebrovascular or cardiovascular disease or overt nephropathy and followed them for a mean of 7.5 years. At baseline, 177 of 608 patients had SCI, diagnosed by cerebral magnetic resonance imaging. The risk for the primary outcome of ESRD or death was significantly higher for patients with SCI than for patients without SCI [hazard ratio, 2.44; 95% confidence interval (CI) 1.36 to 4.38]. The risk for the secondary renal end point of any dialysis or doubling of the serum creatinine concentration was also significantly higher for patients with SCI (hazard ratio, 4.79; 95% CI 2.72 to 8.46). The estimated GFR declined more in patients with SCI than in those without SCI; however, the presence of SCI did not increase the risk for progression of albuminuria. In conclusion, independent of microalbuminuria, cerebral microvascular disease predicted renal morbidity among patients with type 2 diabetes. |
| | |
Authors:
|
Takashi Uzu; Yasuo Kida; Nobuo Shirahashi; Tamaki Harada; Atsushi Yamauchi; Makoto Nomura; Keiji Isshiki; Shin-Ichi Araki; Toshiro Sugimoto; Daisuke Koya; Masakazu Haneda; Atsunori Kashiwagi; Ryuichi Kikkawa |
Publication Detail:
|
Type: Journal Article Date: 2010-01-28 |
Journal Detail:
|
Title: Journal of the American Society of Nephrology : JASN Volume: 21 ISSN: 1533-3450 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-03-01 Completed Date: 2010-03-25 Revised Date: 2011-07-25 |
Medline Journal Info:
|
Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
|
Languages: eng Pagination: 520-6 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan. takuzu@belle.shiga-med.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Albuminuria / epidemiology Cerebrovascular Circulation Cerebrovascular Disorders / epidemiology*, pathology Diabetes Mellitus, Type 2 / epidemiology*, pathology Diabetic Nephropathies / epidemiology* Female Follow-Up Studies Glomerular Filtration Rate Humans Incidence Kaplan-Meier Estimate Kidney Failure, Chronic / epidemiology* Magnetic Resonance Angiography Male Microvessels / pathology Middle Aged Morbidity Predictive Value of Tests Proportional Hazards Models Risk Factors |
| Comments/Corrections | |
Comment In:
|
Nat Rev Nephrol. 2010 May;6(5):250
[PMID:
20440867
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spontaneous remission of nephrotic syndrome in idiopathic membranous nephropathy.
Next Document: Immune phenotype predicts risk for posttransplantation squamous cell carcinoma.