Document Detail


Cerebral microbleeds in the elderly: a pathological analysis.
MedLine Citation:
PMID:  21030702     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Cerebral microbleeds in the elderly are routinely identified by brain MRI. The purpose of this study was to better characterize the pathological basis of microbleeds.
METHODS: We studied postmortem brain specimens of 33 individuals with no clinical history of stroke and with an age range of 71 to 105 years. Cerebral microbleeds were identified by presence of hemosiderin (iron), identified by routine histochemistry and Prussian blue stain. Cellular localization of iron (in macrophages and pericytes) was studied by immunohistochemistry for smooth muscle actin, CD68, and, in selected cases, electron microscopy. Presence of β-amyloid was analyzed using immunohistochemistry for epitope 6E10.
RESULTS: Cerebral microbleeds were present in 22 cases and occurred at capillary, small artery, and arteriolar levels. Presence of microbleeds occurred independent of amyloid deposition at site of microbleeds. Although most subjects had hypertension, microbleeds were present with and without hypertension. Putamen was the site of microbleeds in all but 1 case; 1 microbleed was in subcortical white matter of occipital lobe. Most capillary microbleeds involved macrophages, but the 2 microbleeds studied by electron microscopy demonstrated pericyte involvement.
CONCLUSIONS: These findings indicate that cerebral microbleeds are common in elderly brain and can occur at the capillary level.
Authors:
Mark Fisher; Samuel French; Ping Ji; Ronald C Kim
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-28
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  41     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  2010-12-22     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2782-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of California, Irvine, CA 92868, USA. mfisher@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Aged / physiology*
Aged, 80 and over
Basal Ganglia / pathology
Brain / growth & development,  pathology*
Capillaries / pathology
Cell Movement
Cerebral Amyloid Angiopathy / pathology
Cerebral Cortex / pathology
Cerebral Hemorrhage / pathology*
Female
Follow-Up Studies
Humans
Immunohistochemistry
Macrophages / pathology
Magnetic Resonance Imaging
Male
Microscopy, Electron
Pericytes / pathology
Grant Support
ID/Acronym/Agency:
AA8116/AA/NIAAA NIH HHS; P50 AG000658/AG/NIA NIH HHS; P50 AG16573/AG/NIA NIH HHS; R01 NS020989-23/NS/NINDS NIH HHS; R01 NS20989/NS/NINDS NIH HHS; R01AG21055/AG/NIA NIH HHS
Comments/Corrections
Comment In:
Stroke. 2011 Apr;42(4):e368   [PMID:  21330630 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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