| Cerebral microbleeds in the elderly: a pathological analysis. | |
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MedLine Citation:
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PMID: 21030702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Cerebral microbleeds in the elderly are routinely identified by brain MRI. The purpose of this study was to better characterize the pathological basis of microbleeds. METHODS: We studied postmortem brain specimens of 33 individuals with no clinical history of stroke and with an age range of 71 to 105 years. Cerebral microbleeds were identified by presence of hemosiderin (iron), identified by routine histochemistry and Prussian blue stain. Cellular localization of iron (in macrophages and pericytes) was studied by immunohistochemistry for smooth muscle actin, CD68, and, in selected cases, electron microscopy. Presence of β-amyloid was analyzed using immunohistochemistry for epitope 6E10. RESULTS: Cerebral microbleeds were present in 22 cases and occurred at capillary, small artery, and arteriolar levels. Presence of microbleeds occurred independent of amyloid deposition at site of microbleeds. Although most subjects had hypertension, microbleeds were present with and without hypertension. Putamen was the site of microbleeds in all but 1 case; 1 microbleed was in subcortical white matter of occipital lobe. Most capillary microbleeds involved macrophages, but the 2 microbleeds studied by electron microscopy demonstrated pericyte involvement. CONCLUSIONS: These findings indicate that cerebral microbleeds are common in elderly brain and can occur at the capillary level. |
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Authors:
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Mark Fisher; Samuel French; Ping Ji; Ronald C Kim |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-28 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 41 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-30 Completed Date: 2010-12-22 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2782-5 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of California, Irvine, CA 92868, USA. mfisher@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged
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physiology* Aged, 80 and over Basal Ganglia / pathology Brain / growth & development, pathology* Capillaries / pathology Cell Movement Cerebral Amyloid Angiopathy / pathology Cerebral Cortex / pathology Cerebral Hemorrhage / pathology* Female Follow-Up Studies Humans Immunohistochemistry Macrophages / pathology Magnetic Resonance Imaging Male Microscopy, Electron Pericytes / pathology |
| Grant Support | |
ID/Acronym/Agency:
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AA8116/AA/NIAAA NIH HHS; P50 AG000658/AG/NIA NIH HHS; P50 AG16573/AG/NIA NIH HHS; R01 NS020989-23/NS/NINDS NIH HHS; R01 NS20989/NS/NINDS NIH HHS; R01AG21055/AG/NIA NIH HHS |
| Comments/Corrections | |
Comment In:
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Stroke. 2011 Apr;42(4):e368
[PMID:
21330630
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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