| Cerebral microbleeds are uncommon in ischemic stroke associated with nonvalvular atrial fibrillation. | |
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MedLine Citation:
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PMID: 19888932 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Patients with cardioembolic ischemic stroke from nonvalvular atrial fibrillation (NVAF) are candidates for long-term anticoagulation. This study examines the prevalence of cerebral microbleeds (MBs) in stroke patients with NVAF. METHODS: A total of 132 consecutive ischemic stroke patients with NVAF admitted to our Stroke Unit were recruited if complete magnetic resonance (MR) imaging studies including T2* imaging had been performed within less than 72 hours. National Institutes of Health Stroke Scale scores were documented and cerebrovascular risk factors were monitored. RESULTS: Among 132 patients (mean age 74.1 ± 9.8 years), only 9 (6.8%) had MBs (mean number 6.2) as detected on T2* MR images. No statistically significant differences between patients without versus with MBs were observed regarding arterial hypertension, diabetes, hyperlipidemia, and coronary heart disease. However, small vessel disease (SVD) was significantly more frequent in patients with MBs than without MBs (44.4% vs. 12.2%; P < .05) and significantly more patients with MBs experienced repeated strokes (44.4% vs. 14.6%; P < .05). CONCLUSIONS: In contrast to studies reflecting a high incidence of MBs in stroke patients of various subtypes, MBs occurred less frequently in patients with cardioembolic acute ischemic stroke associated with NVAF. In patients with severe SVD or repeated cerebrovascular events, special caution should be taken regarding oral anticoagulation. |
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Authors:
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Anastasios Chatzikonstantinou; Olaf Willmann; Kristina Szabo; Michael G Hennerici |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: 103-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 by the American Society of Neuroimaging. |
Affiliation:
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From the Department of Neurology, Universitätsklinikum Mannheim, Ruprecht-Karls-Universität Heidelberg, Mannheim, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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