| Cerebral Magnetic Resonance Spectroscopy at 7 Tesla: Standard Values and Regional Differences. | |
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MedLine Citation:
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PMID: 21377907 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: At lower magnetic field strengths, regional differences of cerebral metabolite distributions have been described, but these data are controversial. Magnetic resonance spectroscopy at 7 T is expected to deliver high spectral resolution and good differentiation, but there are problems arising at high magnetic field strengths that may diminish spectral quality. Because there have been only a few studies in humans so far, there are no standard values for 7 T concerning regional metabolite distributions and concentrations. MATERIALS AND METHODS: In the present study, the metabolites detectable with (1)H magnetic resonance spectroscopy, N-acetyl-aspartate, choline, and creatine (Cr), were evaluated with a single-voxel sequence. Five voxels were placed in the frontal and parietal white matter and the insular, thalamic, and occipital gray matter. RESULTS: For N-acetyl-aspartate, the lowest values were found in frontal white matter and the highest in thalamic gray matter. Choline displayed the lowest values in frontal white matter and the highest in insular gray matter. Cr showed the lowest values in frontal white matter and the highest in thalamic gray matter. The highest ratio of choline to Cr was found in parietal white matter and the lowest in thalamic gray matter. The highest ratio of N-acetyl-aspartate to Cr was found in thalamic gray matter and the lowest in frontal white matter. CONCLUSIONS: In the present study, regional cerebral metabolite differences were verified with high-field magnetic resonance spectroscopy. Quantitative values and metabolite ratios could be a basis for further clinical studies. |
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Authors:
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Astrid E Grams; Irina Brote; Stefan Maderwald; Kiriaki Kollia; Mark E Ladd; Michael Forsting; Elke R Gizewski |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-4 |
Journal Detail:
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Title: Academic radiology Volume: - ISSN: 1878-4046 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 AUR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neuroradiology, University Hospital Giessen and Marburg, Justus Liebig University Giessen, Klinikstraße 29, 35392 Giessen, Germany; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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