| Cerebral MRI of very low birth weight children at 6 years of age compared with the findings at 1 year. | |
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MedLine Citation:
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PMID: 9634467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We have previously reported the results of cerebral MRI examinations in an unselected year cohort of very low birth weight (VLBW) infants at one year of corrected age. Twenty-one (78 %) of 27 infants had abnormal myelination, mainly in the central occipital white matter (COWM) and in the centrum semiovale (CS), seen on T2-weighted images. Twelve infants had irregular and dilated lateral ventricles. We speculated whether these findings indicated perinatal periventricular leukomalacia (PVL). Only two infants had completely normal MRI at age 1 year. OBJECTIVE: To determine whether the abnormal myelination seen at 1 year of age, was still present, either as delayed myelination or as gliosis caused by perinatal PVL. MATERIALS AND METHODS: In the present study, we report the results of follow-up cerebral MRI in 20 of these infants at 6 years of age. RESULTS: Most of the children with MRI deviations at 1 year still had abnormalities at 6 years. Abnormal myelination in the central occipital white matter combined with abnormalities in the CS or with ventricular dilatation at age 1 year, presented as gliosis in 12 of 13 children at 6 years of age. Abnormalities solely in the COWM at age 1 year had normalised in two of five children and persisted as delayed myelination in three at age 6 years. Gliotic changes in periventricular white matter were found in 12 of 20 children (60 %). Areas most affected were the CS (11 children) and the COWM (9 children). Delayed myelination in COWM was found in six children (30 %), combined with gliosis in CS in three children. Twelve infants had ventricular dilatation both at 1 and 6 years of age. CONCLUSIONS: The MRI correlates of PVL, i. e. gliosis and ventricular dilatation, are common findings on cerebral MRI at 6 years of age in VLBW infants. |
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Authors:
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J S Skranes; G Nilsen; O Smevik; T Vik; A M Brubakk |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pediatric radiology Volume: 28 ISSN: 0301-0449 ISO Abbreviation: Pediatr Radiol Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-08-14 Completed Date: 1998-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0365332 Medline TA: Pediatr Radiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 471-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Neonatal Medicine, University Hospital of Trondheim, Norway. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Child Cohort Studies Follow-Up Studies Humans Infant Infant, Newborn Infant, Very Low Birth Weight* Leukomalacia, Periventricular / diagnosis* Magnetic Resonance Imaging Time Factors |
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