Document Detail


Cerebral Infarctions After Intravenous Immunoglobulin Therapy for ITP in a Child.
MedLine Citation:
PMID:  24262342     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Intravenous immunoglobulin is the favored therapy in childhood immune thrombocytopenic purpura. It is usually well tolerated with manageable side effects, but venous and arterial thrombosis following its administration have been described, mostly in adults.
METHODS: We describe a 3-year-old girl with immune thrombocytopenic purpura and intracranial hemorrhage who received intravenous immunoglobulin therapy and subsequently developed multifocal cerebral infarctions.
RESULTS: Product specific as well as other factors may play a role in the development of this complication of intravenous immunoglobulin therapy. This is the only reported case of intravenous immunoglobulin-related thrombosis in a child with immune thrombocytopenic purpura and intracranial hemorrhage.
CONCLUSIONS: Thrombotic complications are associated with intravenous immunoglobulin administration and this includes cerebral infarcts.
Authors:
Adonis Lorenzana; Samira Armin; Animesh Sharma; Iqbal Allarakhia; Alina Witkowski
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-27
Journal Detail:
Title:  Pediatric neurology     Volume:  -     ISSN:  1873-5150     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics, St. John Hospital and Medical Center, Grosse Point Woods, Michigan. Electronic address: Adonis.lorenzana@stjohn.org.
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