Document Detail


Cerebral hemodynamics in the presence of decreased systemic venous compliance in patients with Fontan physiology may limit anaerobic exercise capacity.
MedLine Citation:
PMID:  19915888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients who have had the Fontan procedure report poor exercise performance. Fontan subjects can tolerate a higher level of sub maximal activity than might be anticipated from VO2, suggesting a different mechanism of exercise limitation. Near-infrared spectroscopy (NIRS) provides a non-invasive, continuous method to monitor regional tissue oxygenation (rSO2) and thereby a window into regional oxygen supply-demand relationships. We hypothesized that Fontan patients would have altered rSO2 trends from normal population that might reflect the mechanisms of exercise limitation. All the patients without structural or acquired heart disease and Fontan patients were eligible for inclusion if they were ordered to undergo cardiopulmonary exercise testing (CPET). Four-site regional rSO2 were recorded continuously during exercise. The difference between the oxyhemoglobin saturation measured by pulse oximetry (SpO2) and NIRS (rSO2) was computed as the regional arterial-venous saturation difference (AVDO2). A total of 33 normal subjects and five Fontan subjects scheduled for CPET were recruited. None of the Fontan subjects had a fenestration of the conduit. In the cerebral circulation, the Fontan patients have a significantly higher initial slope of increasing AVDO2 compared with normals. After vAT, the AVDO2 slope is flat for Fontan patients (p = 0.02). There is also a substantially larger rebound of cerebral rSO2 than in normal subjects after QT (p < 0.0001). Reduced anaerobic exercise capacity in Fontan patients may be secondary to limitation of cerebral blood flow, secondary to low systemic venous compliance due to absence of a sub-pulmonary ventricle, and augmented hyperventilatory response during exercise.
Authors:
Rohit P Rao; Michael J Danduran; George M Hoffman; Nancy S Ghanayem; Stuart Berger; Peter C Frommelt
Related Documents :
10364738 - Repetitive hemodilution in chronic obstructive pulmonary disease and pulmonary hyperten...
15385258 - Deleterious effect of zinc in a pig model of acute endotoxemia.
3751928 - Effect of nicardipine on rest and exercise hemodynamics in chronic congestive heart fai...
19606798 - Acute pulmonary edema during a triathlon occurrence in a trained athlete.
6927538 - Quantification of dyspnea confirmed by voice pitch analysis.
3534828 - Preparticipation sports examination of the child and adolescent athlete: changing views...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric cardiology     Volume:  31     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-19     Completed Date:  2010-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  208-14     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Cardiology and Critical Care, Medical College of Wisconsin, Milwaukee, WI, USA. rrao@chw.org
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00556231
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anaerobic Threshold*
Case-Control Studies
Cerebrovascular Circulation*
Child
Exercise Tolerance*
Fontan Procedure / adverse effects*
Hemodynamics
Humans
Oximetry / methods
Regional Blood Flow
Spectroscopy, Near-Infrared

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Red Blood Cell Membrane Fluidity in the Etiology of Multiple Sclerosis.
Next Document:  Cardiac Isoform of Alpha 2 Macroglobulin: A Marker of Cardiac Involvement in Pediatric HIV and AIDS.