| Cerebral amyloidosis: postmortem detection with human 7.0-T MR imaging system. | |
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MedLine Citation:
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PMID: 19789230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To explore the ability of whole-body 7.0-T magnetic resonance (MR) imaging to depict differences in aspects of the cerebral cortex of postmortem human brain specimens with cerebral amyloid beta deposition in connection with Alzheimer disease (AD), Down syndrome, or sporadic or hereditary cerebral amyloid angiopathy (CAA) and control brain specimens lacking such deposition. MATERIALS AND METHODS: This study was approved by the local institutional review board. In all cases, informed consent was obtained to perform autopsy and to use the tissues for research purposes. T2- and T2*-weighted MR imaging was performed in formalin-fixed samples of brain tissue from six subjects with AD changes, seven with CAA, and five subjects without immunohistochemical evidence of cerebral amyloid beta deposition. All MR images were visually assessed for hypointense foci in and inhomogeneity of the cortex. Sensitivity, specificity, and kappa values of these MR imaging features in the detection of histologic changes were calculated. RESULTS: High-spatial-resolution 0.3 x 0.3 x 0.3-mm three-dimensional T2*-weighted images revealed hypointense foci, inhomogeneity of the cortex, or both in all specimens with brain amyloid beta deposition. These MR imaging features were observed in none of the control specimens. CONCLUSION: The finding of postmortem susceptibility-weighted changes in the cerebral cortex of patients with cerebral amyloidosis with a human 7.0-T MR imaging system opens up the possibility of obtaining in vivo radiologic evidence of cerebral amyloid beta deposition. |
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Authors:
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Sanneke van Rooden; Marion L C Maat-Schieman; Rob J A Nabuurs; Louise van der Weerd; Sara van Duijn; Sjoerd G van Duinen; Remco Natt??; Mark A van Buchem; Jeroen van der Grond |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-29 |
Journal Detail:
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Title: Radiology Volume: 253 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-02 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 788-96 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Leiden University Medical Center, C3-Q, PO Box 9600, 2300 RC Leiden, The Netherlands. S.van_Rooden@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cadaver Cerebral Amyloid Angiopathy / etiology, pathology* Cerebral Cortex / pathology* Humans Image Processing, Computer-Assisted / methods Immunohistochemistry Magnetic Resonance Imaging / methods* Risk Factors Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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