Document Detail


Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: association with allelic variation in GABRA2 and BDNF.
MedLine Citation:
PMID:  22047728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Offspring from families with multiple cases of alcohol dependence have a greater likelihood of developing alcohol dependence (AD) and related substance use disorders. Greater susceptibility for developing these disorders may be related to structural differences in brain circuits that influence the salience of rewards or modify the efficiency of information processing and AD susceptibility. We examined the cerebellum of 71 adolescent/young adult high-risk (HR) offspring from families with multiple cases of alcohol dependence (multiplex families), and 60 low-risk (LR) controls with no family history of alcohol or drug dependence who were matched for age, gender, socioeconomic status and IQ, with attention given to possible effects of personal use of substances and maternal use during pregnancy. Magnetic resonance images were acquired on a General Electric 1.5-Tesla scanner and manually traced (BRAINS2) blind to clinical information. GABRA2 and BDNF variation were tested for their association with cerebellar volumes. High-risk offspring from multiplex AD families showed greater total volume of the cerebellum and total gray matter (GM), in comparison with LR controls. An interaction between allelic variation in GABRA2 and BDNF genes was associated with GM volumes, suggesting that inherited variation in these genes may promote early developmental differences in neuronal proliferation of the cerebellum.
Authors:
Shirley Y Hill; Shuhui Wang; Howard Carter; Kevin Tessner; Brian Holmes; Michael McDermott; Nicholas Zezza; Scott Stiffler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-01
Journal Detail:
Title:  Psychiatry research     Volume:  194     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-01-26     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  304-13     Citation Subset:  IM    
Copyright Information:
2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Factors
Alcoholism / genetics*,  pathology*
Brain Mapping
Brain-Derived Neurotrophic Factor / genetics*
Cerebellum / pathology*
Child of Impaired Parents*
Family Health*
Female
Genetic Variation / genetics*
Genotype
Humans
Image Processing, Computer-Assisted
Linear Models
Magnetic Resonance Imaging
Male
Receptors, GABA-A / genetics*
Sex Factors
Young Adult
Grant Support
ID/Acronym/Agency:
AA 08082/AA/NIAAA NIH HHS; AA015168/AA/NIAAA NIH HHS; AA018289/AA/NIAAA NIH HHS; AA05909/AA/NIAAA NIH HHS; R01 AA005909/AA/NIAAA NIH HHS; R01 AA005909-22/AA/NIAAA NIH HHS; R01 AA008082/AA/NIAAA NIH HHS; R01 AA008082-20/AA/NIAAA NIH HHS; R01 AA015168/AA/NIAAA NIH HHS; R01 AA015168-05/AA/NIAAA NIH HHS; R01 AA018289/AA/NIAAA NIH HHS; R01 AA018289-04/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/GABRA2 protein, human; 0/Receptors, GABA-A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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