| The cerebellum and pain: passive integrator or active participator? | |
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MedLine Citation:
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PMID: 20553761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cerebellum is classically considered to be a brain region involved in motor processing, but it has also been implicated in non-motor, and even cognitive, functions. Though previous research suggests that the cerebellum responds to noxious stimuli, its specific role during pain is unclear. Pain is a multidimensional experience that encompasses sensory discriminative, affective motivational, and cognitive evaluative components. Cerebellar involvement during the processing of pain could thus potentially reflect a number of different functional processes. This review will summarize the animal and human research to date that indicates that (1) primary afferents conduct nociceptive (noxious) input to the cerebellum, (2) electrical and pharmacological stimulation of the cerebellum can modulate nociceptive processing, and (3) cerebellar activity occurs during the presence of acute and chronic pain. Possible functional roles for the cerebellum relating to pain will be considered, including perspectives relating to emotion, cognition, and motor control in response to pain. |
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Authors:
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Eric A Moulton; Jeremy D Schmahmann; Lino Becerra; David Borsook |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-05-27 |
Journal Detail:
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Title: Brain research reviews Volume: 65 ISSN: 1872-6321 ISO Abbreviation: Brain Res Rev Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-01-07 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 101300366 Medline TA: Brain Res Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 14-27 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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P.A.I.N. Group, Brain Imaging Center, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA. emoulton@mclean.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticipation, Psychological Behavior / physiology Cerebellum / anatomy & histology, physiopathology* Cerebral Cortex / physiopathology Emotions / physiology Humans Neural Pathways / physiopathology Neurons, Afferent / physiology Nociceptors / physiology Pain / complications, physiopathology*, psychology Pain Perception / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DA25289/DA/NIDA NIH HHS; K01 DA025289-02/DA/NIDA NIH HHS; K01 DA025289-03/DA/NIDA NIH HHS; K24 NS064050/NS/NINDS NIH HHS; K24 NS064050-02/NS/NINDS NIH HHS; NS064050/NS/NINDS NIH HHS |
| Comments/Corrections | |
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