Document Detail


The cerebellum and pain: passive integrator or active participator?
MedLine Citation:
PMID:  20553761     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cerebellum is classically considered to be a brain region involved in motor processing, but it has also been implicated in non-motor, and even cognitive, functions. Though previous research suggests that the cerebellum responds to noxious stimuli, its specific role during pain is unclear. Pain is a multidimensional experience that encompasses sensory discriminative, affective motivational, and cognitive evaluative components. Cerebellar involvement during the processing of pain could thus potentially reflect a number of different functional processes. This review will summarize the animal and human research to date that indicates that (1) primary afferents conduct nociceptive (noxious) input to the cerebellum, (2) electrical and pharmacological stimulation of the cerebellum can modulate nociceptive processing, and (3) cerebellar activity occurs during the presence of acute and chronic pain. Possible functional roles for the cerebellum relating to pain will be considered, including perspectives relating to emotion, cognition, and motor control in response to pain.
Authors:
Eric A Moulton; Jeremy D Schmahmann; Lino Becerra; David Borsook
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-27
Journal Detail:
Title:  Brain research reviews     Volume:  65     ISSN:  1872-6321     ISO Abbreviation:  Brain Res Rev     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-07     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101300366     Medline TA:  Brain Res Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  14-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticipation, Psychological
Behavior / physiology
Cerebellum / anatomy & histology,  physiopathology*
Cerebral Cortex / physiopathology
Emotions / physiology
Humans
Neural Pathways / physiopathology
Neurons, Afferent / physiology
Nociceptors / physiology
Pain / complications,  physiopathology*,  psychology
Pain Perception / physiology
Grant Support
ID/Acronym/Agency:
DA25289/DA/NIDA NIH HHS; K01 DA025289/DA/NIDA NIH HHS; K24 NS064050/NS/NINDS NIH HHS; NS064050/NS/NINDS NIH HHS
Comments/Corrections

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