Document Detail


The cerebellum and basal ganglia are interconnected.
MedLine Citation:
PMID:  20811947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cerebellum and the basal ganglia are major subcortical nuclei that control multiple aspects of behavior largely through their interactions with the cerebral cortex. Discrete multisynaptic loops connect both the cerebellum and the basal ganglia with multiple areas of the cerebral cortex. Interactions between these loops have traditionally been thought to occur mainly at the level of the cerebral cortex. Here, we review a series of recent anatomical studies in nonhuman primates that challenge this perspective. We show that the anatomical substrate exists for substantial interactions between the cerebellum and the basal ganglia. Furthermore, we discuss how these pathways may provide a useful framework for understanding cerebellar contributions to the manifestation of two prototypical basal ganglia disorders, Parkinson's disease and dystonia.
Authors:
Andreea C Bostan; Peter L Strick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-09-03
Journal Detail:
Title:  Neuropsychology review     Volume:  20     ISSN:  1573-6660     ISO Abbreviation:  Neuropsychol Rev     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2011-01-13     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9009029     Medline TA:  Neuropsychol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-70     Citation Subset:  IM    
Affiliation:
Center for the Neural Basis of Cognition, Systems Neuroscience Institute, and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. acb42@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Basal Ganglia / anatomy & histology*,  pathology
Brain Mapping*
Cerebellum / anatomy & histology*,  pathology
Dystonia / pathology,  physiopathology
Humans
Models, Anatomic
Neural Pathways / pathology,  physiology*
Parkinson Disease / pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
P40 RR018604/RR/NCRR NIH HHS; R01 MH056661-14/MH/NIMH NIH HHS; R01 MH56661/MH/NIMH NIH HHS; R01 NS024328-24/NS/NINDS NIH HHS; R01 NS24328/NS/NINDS NIH HHS
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