Document Detail


Cerebellin1 is a novel orexigenic peptide.
MedLine Citation:
PMID:  20920041     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Cerebellin1 (Cbln1) is highly expressed in the hypothalamus, a region of the brain involved in appetite regulation. However, the effects of Cbn1 on food intake are not known. The present study aimed to investigate the effect of Cbln1 on appetite regulation in rats.
METHODS: We determined the effect of (i) intracerebroventricular (ICV) injection of Cbln1 on food intake, behaviour and plasma pituitary hormone levels in male Wistar rats; (ii) Cbln1 on the release of hypothalamic neuropeptides known to modulate food intake from hypothalamic explants and (iii) fasting on hypothalamic Cbln1 mRNA expression.
RESULTS: (i) ICV administration of Cbln1 significantly increased food intake in rats and caused no adverse behaviours. ICV administration of Cbln1 significantly reduced plasma thyroid stimulating hormone (TSH) levels 10 min postinjection in rats. (ii) Cbln1 significantly increased the release of neuropeptide Y (NPY) from hypothalamic explants. (iii) Cbln1 mRNA expression levels were increased in the ventromedial nucleus of the hypothalamus in fasted rats.
CONCLUSIONS: These data suggest that Cbln1 is a novel orexigenic peptide, which may mediate its effects via hypothalamic NPY.
Authors:
J V Gardiner; K E Beale; D Roy; C K Boughton; A Bataveljic; D C Campbell; G A Bewick; N A Patel; M Patterson; E M Leavy; M A Ghatei; S R Bloom; W S Dhillo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  12     ISSN:  1463-1326     ISO Abbreviation:  Diabetes Obes Metab     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-06-02     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  883-90     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / administration & dosage*
Appetite Regulation / drug effects*,  physiology
Eating / drug effects*
Fasting
Hypothalamus / drug effects*,  physiology
Injections, Intraventricular
Male
Nerve Tissue Proteins / administration & dosage*
Protein Precursors / administration & dosage*
Rats
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Cbln1 protein, rat; 0/Nerve Tissue Proteins; 0/Protein Precursors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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