Document Detail

Cerebellar volume and long-term use of phenytoin.
MedLine Citation:
PMID:  12810345     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To perform MRI cerebellum volumetry in patients exposed to phenytoin and to identify factors associated with cerebellar atrophy (CA).
METHODS: From 100 consecutive epilepsy patients we selected those with phenytoin use for more than 2 months and with MRI scan available for volumetric studies. We obtained cerebellar volumes corrected for total intracranial volume. Volumes below 2 standard deviations from the mean of control group were considered abnormal.
RESULTS: We studied 56 patients (33 women). Mean age was 33.6 years and mean duration of epilepsy was 17.6 years. Mean daily dose of phenytoin was 301 mg. CA was detected in 20 (35.7%) patients. CA was not associated with frequent generalised seizures. CA correlated with duration of epilepsy (r=-0.34; P=0.01) and years of treatment with phenytoin (r=-0.48; P=0.001), but not with age and mean daily dosage of phenytoin (P>0.05). However, a multiple correlation analysis as well as a backward stepwise multiple regression analysis including all variables showed that only duration of treatment was significantly associated with CA (P=0.001).
CONCLUSIONS: CA is frequently associated with long-term use of phenytoin. Although duration of epilepsy may have an influence in the CA, this is clearly less important than the time of exposure to phenytoin.
Felipe Antonio De Marcos; Enrico Ghizoni; Elaine Kobayashi; Li Min Li; Fernano Cendes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Seizure     Volume:  12     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-17     Completed Date:  2003-12-09     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  312-5     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / administration & dosage,  adverse effects*,  pharmacokinetics
Cerebellum / drug effects*,  pathology
Child, Preschool
Dose-Response Relationship, Drug
Epilepsies, Partial / blood,  diagnosis,  drug therapy
Epilepsy / blood,  diagnosis,  drug therapy*
Epilepsy, Generalized / blood,  diagnosis,  drug therapy
Epilepsy, Temporal Lobe / blood,  diagnosis,  drug therapy
Epilepsy, Tonic-Clonic / blood,  diagnosis,  drug therapy
Image Processing, Computer-Assisted*
Long-Term Care
Magnetic Resonance Imaging*
Mathematical Computing*
Middle Aged
Phenytoin / administration & dosage,  adverse effects*,  pharmacokinetics
Reference Values
Regression Analysis
Risk Factors
Reg. No./Substance:
0/Anticonvulsants; 6158TKW0C5/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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