Document Detail


Cerebellar role in the load-compensating response of expiratory muscle.
MedLine Citation:
PMID:  7836126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothesis that the cerebellum is involved in the load-compensating response of expiratory muscles to expiratory tracheal occlusion was tested in anesthetized cats. A continuous expiratory threshold load (ETL; 5 cmH2O) was applied to elicit consistent phasic baseline electromyographic activity in the transversus abdominis muscle (EMGab). Tracheal occlusion for single expirations (TOE) were applied, and the evoked responses were compared in the intact and decerebellate preparation. Cold blockade of the dorsal spinal column (C5-7) and bilateral vagal inactivation (cold blockade or transection) were employed to determine the role of afferents from the lung, airways, chest wall, and diaphragm in shaping the cerebellar involvement in the motor response. The results showed that 1) decerebellation increased the baseline amplitude of the integrated EMGab (fEMGab) activity (P < 0.05) with little change in expiratory duration, 2) TOE applied after decerebellation markedly increased the expiratory duration compared with the intact values (P < 0.05), with little effect on the peak fEMGab, 3) cooling the dorsal spinal columns (C5-7) did not significantly affect EMGab responses in the intact or decerebellate preparations, and 4) vagal inactivation in the intact or decerebellate preparation significantly eliminated the fEMGab responses to ETL and TOE. We conclude that the cerebellum is involved in the modulation of transversus abdominis activity during ETL and TOE. Vagal afferents provide the major sensory input for the cerebellar modulation of the expiratory loading response.
Authors:
F Xu; D T Frazier
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  77     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-02-28     Completed Date:  1995-02-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1232-8     Citation Subset:  IM; S    
Affiliation:
Department of Physiology, University of Kentucky, Lexington 45036.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Muscles / innervation,  physiology
Animals
Blood Gas Analysis
Blood Pressure / physiology
Cats
Cerebellum / physiology*
Cold Temperature
Electromyography
Female
Male
Neurons, Afferent / physiology
Respiratory Muscles / innervation,  physiology*
Vagotomy
Vagus Nerve / physiology
Grant Support
ID/Acronym/Agency:
HL-40369/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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