Document Detail


Cerebellar peduncle injury in patients with ataxia following diffuse axonal injury.
MedLine Citation:
PMID:  19505539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
No diffusion tensor imaging (DTI) study has yet investigated ataxia in diffuse axonal injury (DAI). In the current study, we used DTI to investigate cerebellar peduncle lesions of patients who showed severe ataxia following DAI. Six patients with severe ataxia following DAI and six age-and sex-matched control subjects were recruited. DTIs were acquired using a sensitivity-encoding head coil on a 1.5T system. Using DTI-Studio software, three cerebellar peduncles (superior cerebellar peduncle, SCP; middle cerebellar peduncle, MCP; inferior cerebellar peduncle, ICP) were evaluated. In each cerebellar peduncle, fractional anisotropy was estimated using the regions of interest method. We defined a lesion as a fractional anisotropy value two standard deviations below that of normal controls. All six patients had an average of 6.3 lesions (range 3-12). Twenty of 36 total cerebellar peduncles revealed more than one lesion (SCP: 8, ICP: 7, MCP: 5). In each of the 20 cerebellar peduncles, all the lesions displaying the lowest FA values relative to that of normal controls (11 peduncles; 55%) were located in the junction between brain stem and cerebellum and post-junctional area (nine peduncles; 45%). The junction and peri-junctional areas between the brain stem and cerebellum appear to be the most vulnerable area by DAI, with the order of incidence SCP, ICP, and MCP. Evaluation of the cerebellar peduncles using DTI can be helpful in patients with ataxia following DAI.
Authors:
Ji Heon Hong; Oh Lyong Kim; Seong Ho Kim; Mi Young Lee; Sung Ho Jang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-06
Journal Detail:
Title:  Brain research bulletin     Volume:  80     ISSN:  1873-2747     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  IM    
Affiliation:
Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namku, Taegu, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anisotropy
Ataxia* / etiology,  pathology
Cerebellum / pathology*
Diffuse Axonal Injury* / complications,  pathology
Diffusion Magnetic Resonance Imaging / methods
Female
Humans
Male
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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