Document Detail


Cerebellar injury in term infants: clinical characteristics, magnetic resonance imaging findings, and outcome.
MedLine Citation:
PMID:  19520266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although cerebellar injury in the premature infant is an increasingly recognized form of neonatal brain injury, its structural and functional outcomes remain poorly defined in the term infant. The objective of this cross-sectional study was to characterize the clinical and magnetic resonance imaging features and neurodevelopmental outcome in children, born at term, with cerebellar injury. Over a 5-year period, 20 infants were identified with ischemic (n = 3) or hemorrhagic (n = 17) cerebellar injury. Lesions were small (<1 cm) in 12 cases, and large in 8 cases. Prenatal and intrapartum factors frequently documented in term infants with cerebellar injury included primiparity (55%), advanced maternal age (30%), group B streptococcus-positive mothers (35%), abnormal fetal heart rate (35%), instrumented delivery (30%), and cesarean section (25%). At follow-up of 18 cases (median age, 32 months), 39% had neurologic abnormalities. Gross motor delays, expressive language deficits, and externalizing behavioral problems were the most common (44%). Cognitive deficits were present in one third of cases. Larger cerebellar lesions were associated with significantly lower cognitive, gross motor, expressive language, and social-behavioral scores. Cerebellar injury in the term infant is associated with a broad spectrum of neurodevelopmental disabilities, particularly in infants with large cerebellar lesions.
Authors:
Catherine Limperopoulos; Richard L Robertson; Nancy R Sullivan; Haim Bassan; Adré J du Plessis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric neurology     Volume:  41     ISSN:  1873-5150     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-08-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada. catherine.limperopoulos@mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Brain Ischemia / complications*,  etiology,  pathology*
Cerebellum / injuries*,  pathology*
Cerebral Hemorrhage / complications*,  etiology,  pathology*
Cesarean Section / contraindications
Child Development
Cognition Disorders / etiology
Cross-Sectional Studies
Extraction, Obstetrical / contraindications
Female
Follow-Up Studies
Heart Rate, Fetal
Humans
Infant, Newborn
Magnetic Resonance Imaging
Male
Mothers
Nervous System Diseases / etiology
Pregnancy
Pregnancy Complications, Infectious
Streptococcal Infections / complications
Streptococcus agalactiae

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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