Document Detail


Cerebellar injury in the premature infant is associated with impaired growth of specific cerebral regions.
MedLine Citation:
PMID:  20389260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have shown that cerebellar injury in the premature infant is followed by significant growth impairment of the contralateral cerebral hemisphere evident as early as term adjusted age. In this study, we hypothesize that this remote growth restriction is region specific in the cerebrum. In a prospectively enrolled cohort of 38 expreterm infants with isolated cerebellar injury by neonatal MRI, we performed follow-up volumetric MRI studies at a mean postnatal age of 35.5 +/- 13.8 mo. We measured volumes of cortical and subcortical gray matter, and cerebral white matter within eight parcellated regions for each cerebral hemisphere. Unilateral cerebellar injury (n = 24) was associated with significantly smaller volumes of cortical gray and cerebral white matter in the following regions of the contralateral (versus ipsilateral) cerebral hemisphere: dorsolateral prefrontal, premotor (PM), sensorimotor, and midtemporal regions (p < 0.001 for all except midtemporal cortical gray, p = 0.01), as well as subcortical gray matter in the PM region (p < 0.001). Conversely, in cases of bilateral cerebellar injury (n = 14), there was no significant interhemispheric difference in tissue volumes for any of the cerebral regions studied. These findings suggest that regional cerebral growth impairment results from interruption of cerebellocerebral connectivity and loss of neuronal activation critical for development.
Authors:
Catherine Limperopoulos; Gevorg Chilingaryan; Nicolas Guizard; Richard L Robertson; Adré J Du Plessis
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  68     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Affiliation:
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada. catherine.limperopoulos@childrens.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Cerebellum / anatomy & histology,  growth & development,  injuries*,  pathology
Cerebral Cortex* / anatomy & histology,  growth & development,  pathology
Female
Gestational Age
Humans
Infant, Newborn* / growth & development
Infant, Premature* / growth & development
Magnetic Resonance Imaging
Male
Prospective Studies
Grant Support
ID/Acronym/Agency:
K24NS057568/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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