| Cerebellar induced aphasia: case report of cerebellar induced prefrontal aphasic language phenomena supported by SPECT findings. | |
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MedLine Citation:
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PMID: 8994102 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 73-year-old right-handed man with ischemic infarction in the vascular territory of the right arteria cerebellaris superior is described. In the acute phase he presented with cerebellar and brainstem symptoms, followed within a few days by a paresis of the right arm and unexpected language disturbances of aphasic origin. The core features of the aphasic syndrome corresponded to a diagnosis of Luria's dynamic aphasia, complicated by expressive and receptive agrammatism. During one year follow-up the ataxia and paretic symptoms disappeared but the slightly ameliorated aphasic syndrome and the sensory disturbances in the left hemicorpus persisted. In the absence of any neuroradiological evidence for a structural lesion in the left frontal language areas, the hypothetical causative role of the right cerebellar lesion on the contralateral prefrontal aphasic symptomatology is advocated and supported by positive 99mTc-hexamethylpropyleneamine oxime single-photon emission-computed tomography findings, revealing a focal hypoperfusion in the clinically suspected areas. In our case, this phenomenon of so-called 'crossed cerebello-cerebral diaschisis', reflecting the distant functional impact of the right cerebellum on the contralateral prefrontal cortical areas, is for the first time associated with an aphasiologic substrate. The co-occurrence of a right cerebellar lesion and an aphasic syndrome forms the first clinical illustration of the pathophysiological hypothesis of a deactivation of prefrontal left hemisphere language functions due to the loss of excitatory impulses through cerebello-ponto-thalamo-cortical pathways. |
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Authors:
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P Mariën; J Saerens; R Nanhoe; E Moens; G Nagels; B A Pickut; R A Dierckx; P P De Deyn |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 144 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-04-15 Completed Date: 1997-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 34-43 Citation Subset: IM |
Affiliation:
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Department of Neurology, General Hospital Middelheim, Antwerp, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aphasia / etiology, psychology, radionuclide imaging* Brain Ischemia / complications, psychology, radionuclide imaging* Cerebellum / blood supply*, radionuclide imaging Follow-Up Studies Humans Male Neuropsychological Tests Prefrontal Cortex / radionuclide imaging* Tomography, Emission-Computed, Single-Photon Verbal Behavior / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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