| Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. | |
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MedLine Citation:
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PMID: 18310985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nattokinase is used as a health-promoting medicine for preventing thrombosis due to its fibrinolytic activity. Cerebral microbleed is remnant of blood extravasations from the damaged vessels related to cerebral microangiopathies. We report a patient, having used aspirin for secondary stroke prevention, who had an acute cerebellar hemorrhage after taking nattokinase 400 mg daily for 7 consecutive days. In addition to the hemorrhagic lesion, multiple microbleeds were demonstrated on brain MR images. We suggest that nattokinase may increase risk of intracerebral hemorrhage in patients who have bleeding-prone cerebral microangiopathy and are receiving other antithrombotic agent at the same time. |
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Authors:
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Yung-Yee Chang; Jia-Shou Liu; Shung-Lon Lai; Hsiu-Shan Wu; Min-Yu Lan |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-03-03 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 47 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2008-03-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 467-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aspirin
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adverse effects* Diffusion Magnetic Resonance Imaging Female Fibrinolytic Agents / adverse effects* Herb-Drug Interactions* Humans Intracranial Hemorrhages / chemically induced*, radiography Ischemic Attack, Transient / prevention & control Middle Aged Plant Extracts / adverse effects Platelet Aggregation Inhibitors / adverse effects* Self Medication / adverse effects* Stroke / complications Subtilisins / adverse effects* Thrombosis / prevention & control Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Plant Extracts; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; EC 3.4.21.-/Subtilisins; EC 3.4.21.-/nattokinase |
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