Document Detail

Cerebellar development in a baboon model of preterm delivery: impact of specific ventilatory regimes.
MedLine Citation:
PMID:  19458549     Owner:  NLM     Status:  MEDLINE    
Premature infants now have an improved chance of survival, but the impact of respiratory therapies on the brain, particularly the cerebellum, remains unclear. We examined the effects of early nasal continuous positive airway pressure (EnCPAP) ventilation and delayed (Dn) CPAP on the development of the cerebellum in prematurely delivered baboons. The baboons were delivered at 125 +/- 2days of gestation and ventilated for 28 days with either EnCPAP commencing at 24 hours (n = 5) or DnCPAP commencing at 5 days (n = 5). Gestational controls (n = 4) were delivered at 153 days. Cerebella were assessed histologically, and an ontogeny study (90 days to term) was performed to establish values for key cerebellar developmental indicators. Cerebellar weight was reduced in DnCPAP but not EnCPAP animals versus controls; cerebellar/total brain weight ratio was increased in EnCPAP (p < 0.05) versus control and DnCPAP animals. There was no overt damage in the cerebella of any animals, but a microstructural alteration index based on morphological developmental parameters and microglial immunoreactivity was increased in both prematurely delivered cohorts versus controls (p < 0.001) and was higher in DnCPAP than EnCPAP animals (p < 0.05). These results indicate that respiratory regimens can influence cerebellar development and that early compared with delayed extubation to nCPAP seems to be beneficial.
Sandra M Rees; Michelle M Loeliger; Kathryn M Munro; Amy Shields; Penelope A Dalitz; Sandra Dieni; Merran A Thomson; Jacqueline Coalson; Terrie Inder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  68     ISSN:  0022-3069     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-06-30     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-15     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / physiology
Body Weight
Calcium-Binding Proteins / metabolism
Cell Proliferation
Cerebellum / abnormalities*,  pathology,  physiopathology*
Disease Models, Animal
In Situ Nick-End Labeling / methods
Ki-67 Antigen / metabolism
Nerve Tissue Proteins / metabolism
Oligodendroglia / metabolism,  pathology
Organ Size
Premature Birth / pathology*,  physiopathology,  therapy*
Purkinje Cells / metabolism,  pathology
Respiration, Artificial / methods*
Time Factors
Grant Support
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Ki-67 Antigen; 0/Nerve Tissue Proteins

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