| Cerebellar development in a baboon model of preterm delivery: impact of specific ventilatory regimes. | |
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MedLine Citation:
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PMID: 19458549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Premature infants now have an improved chance of survival, but the impact of respiratory therapies on the brain, particularly the cerebellum, remains unclear. We examined the effects of early nasal continuous positive airway pressure (EnCPAP) ventilation and delayed (Dn) CPAP on the development of the cerebellum in prematurely delivered baboons. The baboons were delivered at 125 +/- 2days of gestation and ventilated for 28 days with either EnCPAP commencing at 24 hours (n = 5) or DnCPAP commencing at 5 days (n = 5). Gestational controls (n = 4) were delivered at 153 days. Cerebella were assessed histologically, and an ontogeny study (90 days to term) was performed to establish values for key cerebellar developmental indicators. Cerebellar weight was reduced in DnCPAP but not EnCPAP animals versus controls; cerebellar/total brain weight ratio was increased in EnCPAP (p < 0.05) versus control and DnCPAP animals. There was no overt damage in the cerebella of any animals, but a microstructural alteration index based on morphological developmental parameters and microglial immunoreactivity was increased in both prematurely delivered cohorts versus controls (p < 0.001) and was higher in DnCPAP than EnCPAP animals (p < 0.05). These results indicate that respiratory regimens can influence cerebellar development and that early compared with delayed extubation to nCPAP seems to be beneficial. |
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Authors:
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Sandra M Rees; Michelle M Loeliger; Kathryn M Munro; Amy Shields; Penelope A Dalitz; Sandra Dieni; Merran A Thomson; Jacqueline Coalson; Terrie Inder |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of neuropathology and experimental neurology Volume: 68 ISSN: 0022-3069 ISO Abbreviation: J. Neuropathol. Exp. Neurol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-29 Completed Date: 2009-06-30 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 2985192R Medline TA: J Neuropathol Exp Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 605-15 Citation Subset: IM |
Affiliation:
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Department of Anatomy Cell Biology, University of Melbourne, Victoria, Australia. s.rees@unimelb.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Body Weight Calcium-Binding Proteins / metabolism Cell Proliferation Cerebellum / abnormalities*, pathology, physiopathology* Disease Models, Animal Female In Situ Nick-End Labeling / methods Ki-67 Antigen / metabolism Nerve Tissue Proteins / metabolism Oligodendroglia / metabolism, pathology Organ Size Papio Pregnancy Premature Birth / pathology*, physiopathology, therapy* Purkinje Cells / metabolism, pathology Respiration Respiration, Artificial / methods* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL074942-01A1/HL/NHLBI NIH HHS; R01 HL074942-OIAI/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Proteins; 0/Ki-67 Antigen; 0/Nerve Tissue Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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